Convergent trends and spatiotemporal patterns of Aedes-borne arboviruses in Mexico and Central America

• Published in: PLoS neglected tropical diseases 2023-09, Vol.17 (9), p.e0011169-e0011169
• Main Authors: Gutierrez, Bernardo, da Silva Candido, Darlan, Bajaj, Sumali, Rodriguez Maldonado, Abril Paulina, Ayala, Fabiola Garces, Rodriguez, María de la Luz Torre, Rodriguez, Adnan Araiza, Arámbula, Claudia Wong, González, Ernesto Ramírez, Martínez, Irma López, Díaz-Quiñónez, José Alberto, Pichardo, Mauricio Vázquez, Hill, Sarah C, Thézé, Julien, Faria, Nuno R, Pybus, Oliver G, Preciado-Llanes, Lorena, Reyes-Sandoval, Arturo, Kraemer, Moritz U G, Escalera-Zamudio, Marina
• Format: Article
• Language: English
• Subjects: Aedes; Analysis; Animals; Anthropogenic factors; Aquatic insects; Arboviruses; Arboviruses - genetics; Biology and life sciences; Case studies; Central America - epidemiology; Comparative analysis; Computer and Information Sciences; Datasets; Dengue fever; Diagnosis; Earth Sciences; Ecology and Environmental Sciences; Epidemics; Epidemiology; Genetic aspects; Genetic vectors; Genomes; Genomics; Genotype & phenotype; Global health; Human diseases; Human influences; Humans; Laboratories; Life Sciences; Medicine and Health Sciences; Mexico - epidemiology; Migration; Mobility; Mosquitoes; North America; People and places; Population; Public health; Santé publique et épidémiologie; Trends; Vector-borne diseases; Viruses; World health
• ISSN: 1935-2735; 1935-2727; 1935-2735
• DOI: 10.1371/journal.pntd.0011169

Aedes-borne arboviruses cause both seasonal epidemics and emerging outbreaks with a significant impact on global health. These viruses share mosquito vector species, often infecting the same host population within overlapping geographic regions. Thus, comparative analyses of the virus evolutionary and epidemiological dynamics across spatial and temporal scales could reveal convergent trends. Focusing on Mexico as a case study, we generated novel chikungunya and dengue (CHIKV, DENV-1 and DENV-2) virus genomes from an epidemiological surveillance-derived historical sample collection, and analysed them together with longitudinally-collected genome and epidemiological data from the Americas. Aedes-borne arboviruses endemically circulating within the country were found to be introduced multiple times from lineages predominantly sampled from the Caribbean and Central America. For CHIKV, at least thirteen introductions were inferred over a year, with six of these leading to persistent transmission chains. For both DENV-1 and DENV-2, at least seven introductions were inferred over a decade. Our results suggest that CHIKV, DENV-1 and DENV-2 in Mexico share evolutionary and epidemiological trajectories. The southwest region of the country was determined to be the most likely location for viral introductions from abroad, with a subsequent spread into the Pacific coast towards the north of Mexico. Virus diffusion patterns observed across the country are likely driven by multiple factors, including mobility linked to human migration from Central towards North America. Considering Mexico's geographic positioning displaying a high human mobility across borders, our results prompt the need to better understand the role of anthropogenic factors in the transmission dynamics of Aedes-borne arboviruses, particularly linked to land-based human migration.