Gut microbiota composition and type 2 diabetes: Are these subjects linked Together?

Evidence suggests that changes in the composition of gut microbiota may be linked to metabolic disorders including type 2 diabetes (T2D). The present study aims to evaluate the compositional changes of the intestinal microbiota in patients with T2D as compared to healthy individuals. In this case-co...

Full description

Saved in:
Bibliographic Details
Published in:Heliyon 2024-10, Vol.10 (20), p.e39464, Article e39464
Main Authors: Razavi, Shabnam, Amirmozafari, Nour, Zahedi bialvaei, Abed, Navab-Moghadam, Fatemeh, Khamseh, Mohammad E., Alaei-Shahmiri, Fariba, Sedighi, Mansour
Format: Article
Language:English
Subjects:
Actinobacteria
Bacteroidetes
Firmicutes
Gut microbiota
Metabolic disorder
Real-time qPCR
Type 2 diabetes
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Evidence suggests that changes in the composition of gut microbiota may be linked to metabolic disorders including type 2 diabetes (T2D). The present study aims to evaluate the compositional changes of the intestinal microbiota in patients with T2D as compared to healthy individuals. In this case-control study, there were 18 T2D patients and 18 healthy individuals who served as controls. To profile the gut microbiota in both groups, bacterial DNA was extracted from fecal samples and analyzed using quantitative real-time polymerase chain reaction (qPCR). The study discovered that diabetics had significantly greater frequencies of the genus Bacteroides and the phylum Bacteroidetes than did controls (P = 0.03 and P 
ISSN:2405-8440
2405-8440
DOI:10.1016/j.heliyon.2024.e39464