Differential vulnerability of the dentate gyrus to tauopathies in dementias

The dentate gyrus (DG), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the Alzheimer's type due to Alzheimer's disease (DAT-AD), but less is known about the susceptibility of the DG to other tauopathies. Here,...

Full description

Saved in:
Bibliographic Details
Published in:Acta neuropathologica communications 2023-01, Vol.11 (1), p.1-1, Article 1
Main Authors: Kawles, Allegra, Minogue, Grace, Zouridakis, Antonia, Keszycki, Rachel, Gill, Nathan, Nassif, Caren, Coventry, Christina, Zhang, Hui, Rogalski, Emily, Flanagan, Margaret E, Castellani, Rudolph, Bigio, Eileen H, Mesulam, M Marsel, Geula, Changiz, Gefen, Tamar
Format: Article
Language:English
Subjects:
Advertising executives
Alzheimer Disease - pathology
Alzheimer's disease
Corticobasal Degeneration
Dentate gyrus
Dentate Gyrus - metabolism
Female
Frontotemporal lobar degeneration
Humans
Male
Neurons
Primary progressive aphasia
Supranuclear Palsy, Progressive - pathology
tau Proteins - metabolism
Tauopathies - pathology
Tauopathy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The dentate gyrus (DG), a key hippocampal subregion in memory processing, generally resists phosphorylated tau accumulation in the amnestic dementia of the Alzheimer's type due to Alzheimer's disease (DAT-AD), but less is known about the susceptibility of the DG to other tauopathies. Here, we report stereologic densities of total DG neurons and tau inclusions in thirty-two brains of human participants with autopsy-confirmed tauopathies with distinct isoform profiles-3R Pick's disease (PiD, N = 8), 4R corticobasal degeneration (CBD, N = 8), 4R progressive supranuclear palsy (PSP, N = 8), and 3/4R AD (N = 8). All participants were diagnosed during life with primary progressive aphasia (PPA), an aphasic clinical dementia syndrome characterized by progressive deterioration of language abilities with spared non-language cognitive abilities in early stages, except for five patients with DAT-AD as a comparison group. 51% of total participants were female. All specimens were stained immunohistochemically with AT8 to visualize tau pathology, and PPA cases were stained for Nissl substance to visualize neurons. Unbiased stereological analysis was performed in granule and hilar DG cells, and inclusion-to-neuron ratios were calculated. In the PPA group, PiD had highest mean total (granule + hilar) densities of DG tau pathology (p 
ISSN:2051-5960
2051-5960
DOI:10.1186/s40478-022-01485-7