Natural course of perianal abscess in infants: a real-world study

• Published in: Scientific reports 2023-10, Vol.13 (1), p.18416-18416, Article 18416
• Main Authors: Yin, Wanbin, Li, Yansen, Zhang, Jingfeng, Jiao, Yang, Pei, Wenju, Xu, Xiangjun, Fan, Mingfeng, Xu, Juan, Zhou, Yue, Wang, Shuai, Wei, Yanhua
• Format: Article
• Language: English
• Subjects: 692/308; 692/699; 692/700; Abscesses; Fistula; Fistulae; Humanities and Social Sciences; Infants; multidisciplinary; Patients; Science; Science (multidisciplinary); Surgery
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-45751-7

Natural course of perianal abscess (PA) in infancy remains obscure. This study aimed to investigate the natural course of infants with PA after conservative treatment. A retrospective cohort study was conducted in infants with PA who were treated conservatively (due to the parents’ refusal of surgery), for more than 2 months between 2014 and 2020 at a single tertiary center. 153 patients (149 boys and 4 girls) were identified. The median follow-up was 5.3 years (range 3–8.2 years). Initially, 119 patients (77.8%) were completely cured by conservative treatment, and 34 (22.2%) failed. Among the 34 patients, 23 continued conservative treatment (20 cure, 3 fistula formation) and 11 underwent surgery. After conservative treatment, the rate of fistula formation, abscess recurrence, and new-onset abscess were 15.0%, 4.6%, and 6.5%, respectively. Overall, 139 patients (90.8%) were cured conservatively without surgery, and 11 (7.2%) underwent surgical management. In addition, 3 (2.0%) patients developed fistula-in-ano (under observation). PA in infants may be a time-limited and self-limited condition. Conservative management should be the first choice of treatment in most cases. Longer periods of conservative treatment may achieve better clinical outcomes in selected cases. There will be a percentage of patients (about 10%) that would require surgical treatment.