Current natural bioactive materials in bone and tooth regeneration in dentistry: a comprehensive overview

• Published in: Journal of materials research and technology 2021-07, Vol.13, p.2078-2114
• Main Authors: Tafazoli Moghadam, Ehsan, Yazdanian, Mohsen, Alam, Mostafa, Tebyanian, Hamid, Tafazoli, Ali, Tahmasebi, Elahe, Ranjbar, Reza, Yazdanian, Alireza, Seifalian, Alexander
• Format: Article
• Language: English
• Subjects: Bioactive materials; Bone; Natural; Regeneration; Tooth
• ISSN: 2238-7854
• DOI: 10.1016/j.jmrt.2021.05.089

Tissue regeneration is a vital phenomenon in the skeletal system of human beings during their life span. The structure of bony architecture and teeth are highly dependent to this ongoing procedure to maintain their functional form. Regarding the fundamental function of our skeletal system, all the involved components are at constant risk for injuries and deformations throughout the life. Therefore, in modern medicine, promotion of bone and tooth regeneration has become a critical counter measure to correct these acquired defects. There are numerous ways to address the bone and tooth related erosive pathologies but utilization of natural compounds has gained immense popularity in recent years. These materials provide a broad spectrum of therapeutic agents with a variety of biological characteristics. In this review, a comprehensive exploration has been implemented to extract and categorize the relevant scientific evidence on this issue, based on the source of natural candidates and the potential clinical indications. Database searching presented a considerable data pool with more than 300 references in this field. According to the results, all the proposed items can be categorized in two major groups including scaffolding and osteogenesis (or dentinogenesis) induction. The clinical applicability of a number of them is properly demonstrated in clinical trials but for the rest, more examinations are required to reach a conclusive decision.