Relationships Between Transcranial Doppler Velocity, Von Willebrand Factor, Factor VIII, and Hematological Parameters in Children with Sickle Cell Anemia: A Comparative Cross-Sectional Study

• Published in: Clinical medicine insights. Blood disorders 2022-10, Vol.16
• Main Authors: Enifeni, Eniola Kehinde, Ogbenna, Ann Abiola, Daramola, Alaba Olanrewaju, Adewoyin, Ademola Samson, Olatunya, Oladele Simeon, Temiye, Edamisan
• Format: Article
• Language: English
• Subjects: Cross-sectional studies; Sickle cell anemia; Statistical significance; Velocity
• ISSN: 2634-8535; 2634-8535; 1179-545X
• DOI: 10.1177/26348535221130289

Background and Objectives Sickle cell anemia (SCA) is associated with recurrent acute inflammatory processes. These inflammatory processes could lead to elevation of Factor VIII and Von Willebrand Factor levels, thereby increasing the risk of stroke in SCA children. This study aims to determine vWF/FVIII levels in children with SCA and their association with abnormal transcranial Doppler (TCD). Subjects and Methods This study enrolled 75 children, including 24 SCA cases with normal TCD, 27 SCA cases with abnormal TCD, and 24 Hb AA controls, all aged between 2 and 16 years. Transcranial Doppler (TCD) ultrasound was performed to measure the cerebral blood velocity. Venous blood drawn from each participant was used to determine the levels of von Willebrand Factor Antigen (vWF: Ag) and Factor VIII (FVIII) and the complete blood count (CBC). Relationships among the measured parameters were determined using SPSS version 25. Statistical significance was set at P