MiRNAs as Players in Rhabdomyosarcoma Development

Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood and adolescence, is a rare but aggressive malignancy that originates from immature mesenchymal cells committed to skeletal muscle differentiation. Although RMS is, generally, responsive to the modern multimodal therapeutic appr...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-11, Vol.20 (22), p.5818
Main Authors: Gasparini, Patrizia, Ferrari, Andrea, Casanova, Michela, Limido, Francesca, Massimino, Maura, Sozzi, Gabriella, Fortunato, Orazio
Format: Article
Language:English
Subjects:
Animals
Beckwith-Wiedemann syndrome
Biomarkers
Biomarkers, Tumor - genetics
Cell Differentiation - genetics
Chemotherapy
Chromosome aberrations
Chromosomes
Congenital anomalies
Congenital defects
Cytogenetics
Deregulation
Genes
Genetic factors
Genetic transformation
Humans
Li-Fraumeni syndrome
Medical prognosis
Metastasis
microrna
MicroRNAs
MicroRNAs - genetics
Muscle, Skeletal - pathology
Muscles
Musculoskeletal system
Mutation
Myogenesis
Neurofibromatosis
pediatric tumors
Pediatrics
Regulation
Review
Rhabdomyosarcoma
Rhabdomyosarcoma - genetics
Rhabdomyosarcoma - pathology
RNA, Small Untranslated - genetics
Transcription factors
Tumorigenesis
Tumors
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Description
Summary:Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood and adolescence, is a rare but aggressive malignancy that originates from immature mesenchymal cells committed to skeletal muscle differentiation. Although RMS is, generally, responsive to the modern multimodal therapeutic approaches, the prognosis of RMS depends on multiple variables and for some patients the outcome remains dismal. Further comprehension of the molecular and cellular biology of RMS would lead to identification of novel therapeutic targets. MicroRNAs (miRNAs) are small non-coding RNAs proved to function as key regulators of skeletal muscle cell fate determination and to play important roles in RMS pathogenesis. The purpose of this review is to better delineate the role of miRNAs as a biomarkers or functional leaders in RMS development, so to possibly elucidate some of RMS molecular mechanisms and potentially therapeutically target them to improve clinical management of pediatric RMS.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20225818