Recent Advances in Pharmaceutical Approaches of Antimicrobial Agents for Selective Delivery in Various Administration Routes

Globally, the increase of pathogenic bacteria with antibiotic-resistant characteristics has become a critical challenge in medical treatment. The misuse of conventional antibiotics to treat an infectious disease often results in increased resistance and a scarcity of effective antimicrobials to be u...

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Bibliographic Details
Published in:Antibiotics (Basel) 2023-04, Vol.12 (5), p.822
Main Authors: Marzaman, Ardiyah Nurul Fitri, Roska, Tri Puspita, Sartini, Sartini, Utami, Rifka Nurul, Sulistiawati, Sulistiawati, Enggi, Cindy Kristina, Manggau, Marianti A, Rahman, Latifah, Shastri, Venkatram Prasad, Permana, Andi Dian
Format: Article
Language:English
Subjects:
Antibacterial materials
Antibiotic resistance
Antibiotics
Antimicrobial agents
Antimicrobial resistance
antimicrobials
Bacteria
Bacterial infections
Biofilms
Communicable diseases
Comparative analysis
Drug delivery
Drug delivery systems
Drug resistance
Drug resistance in microorganisms
Drugs
Enzymes
Gram-positive bacteria
Hyaluronic acid
Infectious diseases
Medical treatment
Methicillin
Microorganisms
Nanoparticles
Pathogens
pharmaceutical preparations
Publishing industry
Review
selective delivery
Skin
Staphylococcus infections
System effectiveness
Ultrasonic imaging
Vehicles
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Summary:Globally, the increase of pathogenic bacteria with antibiotic-resistant characteristics has become a critical challenge in medical treatment. The misuse of conventional antibiotics to treat an infectious disease often results in increased resistance and a scarcity of effective antimicrobials to be used in the future against the organisms. Here, we discuss the rise of antimicrobial resistance (AMR) and the need to combat it through the discovery of new synthetic or naturally occurring antibacterial compounds, as well as insights into the application of various drug delivery approaches delivered via various routes compared to conventional delivery systems. AMR-related infectious diseases are also discussed, as is the efficiency of various delivery systems. Future considerations in developing highly effective antimicrobial delivery devices to address antibiotic resistance are also presented here, especially on the smart delivery system of antibiotics.
ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics12050822