Changes in Invasive Neisseria meningitidis and Haemophilus influenzae Infections in France during the COVID-19 Pandemic

BackgroundSince the appearance of COVID-19 in January 2020, invasive bacterial infections have decreased significantly worldwide. However, alterations in age and sex distributions, clinical forms, phenotypes, and genotypes of isolates have not been analyzed. Our goal is to present and discuss these...

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Bibliographic Details
Published in:Microorganisms (Basel) 2022-04, Vol.10 (5), p.907
Main Authors: Deghmane, Ala-Eddine, Taha, Muhamed-Kheir
Format: Article
Language:English
Subjects:
Adults
Age
Age groups
Bacteria
Bacterial diseases
Bacterial infections
Coronaviruses
COVID-19
Disease transmission
Epidemiology
Evolution
Gene sequencing
Genomes
Genotypes
Haemophilus influenzae
invasive bacterial infections
Life Sciences
Neisseria meningitidis
Pandemics
Phenotypes
Serotypes
Sex
Streptococcus infections
Trends
Vaccination
Whole genome sequencing
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Summary:BackgroundSince the appearance of COVID-19 in January 2020, invasive bacterial infections have decreased significantly worldwide. However, alterations in age and sex distributions, clinical forms, phenotypes, and genotypes of isolates have not been analyzed. Our goal is to present and discuss these data considering the current COVID-19 pandemic situation. Methods: The data of the national reference center for meningococci and Haemophilus influenzae in France were mined to examine the above aspects of invasive bacterial infection before (2018−2019) and after (2020−2021) the COVID-19 pandemic. Detailed epidemiological, clinical, and microbiological data were collected, and whole genome sequencing was carried out on meningococcal isolates (n = 1466). Results: In addition to the overall decline in the number of cases, various changes in age, sex, and phenotypes of isolates were also noted. As for N. meningitidis, more cases were observed in adults, as well as more invasive pneumopathies. Furthermore, fewer hyperinvasive meningococcal genotypes have circulated since COVID-19 emerged. The situation has been different for H. influenzae, as the number of invasive cases among adults decreased due to a reduction in non-typeable isolates. In contrast, cases due to serotypeable isolates, particularly serotypes a and b, increased in children
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms10050907