Longitudinal changes in complete avascular area assessed using anterior segmental optical coherence tomography angiography in filtering trabeculectomy bleb

Optical coherence tomography angiography (OCTA) is a new technique for non-invasive imaging of blood vessels, allowing combined evaluation of both deep and surface vessels. The purpose of this study was to evaluate the post-trabeculectomy longitudinal changes in complete avascular area (CAA) of filt...

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Bibliographic Details
Published in:Scientific reports 2021-12, Vol.11 (1), p.23418-23418, Article 23418
Main Authors: Kido, Ai, Akagi, Tadamichi, Ikeda, Hanako Ohashi, Kameda, Takanori, Suda, Kenji, Miyake, Masahiro, Hasegawa, Tomoko, Numa, Shogo, Tsujikawa, Akitaka
Format: Article
Language:English
Subjects:
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692/308/53
Adult
Aged
Angiography
Blood flow
Blood vessels
Computed Tomography Angiography
Female
Glaucoma - diagnostic imaging
Glaucoma - surgery
Humanities and Social Sciences
Humans
Intraocular Pressure
Longitudinal Studies
Male
Medical imaging
Middle Aged
Mitomycin - administration & dosage
Mitomycin - pharmacology
Mitomycin C
multidisciplinary
Prospective Studies
Science
Science (multidisciplinary)
Surgical outcomes
Tomography
Tomography, Optical Coherence - methods
Trabeculectomy - methods
Treatment Outcome
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Summary:Optical coherence tomography angiography (OCTA) is a new technique for non-invasive imaging of blood vessels, allowing combined evaluation of both deep and surface vessels. The purpose of this study was to evaluate the post-trabeculectomy longitudinal changes in complete avascular area (CAA) of filtering blebs using anterior segment (AS-) OCTA and their association with surgical outcomes. This study included 57 eyes of 53 patients who had undergone trabeculectomy with mitomycin C. AS-OCTA images of filtering bleb were acquired at 3 and 6 months after trabeculectomy, and at 1 month in possible cases. CAAs, regions where complete blood flow was not depicted in AS-OCTA images, were evaluated for their presence, extent, and change over time. CAAs were detected in 37 eyes (65%) and 33 eyes (58%) at 3 and 6 months postoperatively, respectively. The extent of CAAs reduced over time after surgery in most cases. No parameters related to CAAs were significantly associated with surgical success (i.e., intraocular pressure (IOP) ≤ 12 mmHg and IOP reduction > 20% without medication). In conclusion, although it is difficult to predict surgical success by CAA itself, AS-OCTA may be useful for the objective evaluation of the vascularity of filtering blebs.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-02871-2