Association of neutrophil-to-lymphocyte ratio (NLR) with the prognosis of first attack neuromyelitis optica spectrum disorder (NMOSD): a retrospective cohort study

Background To investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and prognosis after the first attack of optic neuromyelitis optica spectrum disorder (NMOSD). Methods In this retrospective study, we included the medical records of 324 patients with first episode NMOSD and...

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Bibliographic Details
Published in:BMC neurology 2021-10, Vol.21 (1), p.1-389, Article 389
Main Authors: Xie, Haojie, Zhao, Yi, Pan, Chunyang, Zhang, Jinwei, Zhou, Yongyan, Li, Yanfei, Duan, Ranran, Yao, Yaobing, Gong, Zhe, Teng, Junfang, Jia, Yanjie
Format: Article
Language:English
Subjects:
Age
Antibodies
Biomarkers
Blood
Cohort analysis
Cytokines
Disease
Extended disability status scale
First attack
Hypertension
Immunosuppressive agents
Laboratories
Leukocytes (neutrophilic)
Lymphocytes
Medical records
Medical research
Monocytes
Multiple sclerosis
Multivariate analysis
Nervous system
Neuromyelitis
Neuromyelitis optica spectrum disorder
Neutrophil-to-lymphocyte ratio
Neutrophils
Normal distribution
Pathogenesis
Patients
Prognosis
Regression analysis
Sex ratio
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Summary:Background To investigate the relationship between the neutrophil-to-lymphocyte ratio (NLR) and prognosis after the first attack of optic neuromyelitis optica spectrum disorder (NMOSD). Methods In this retrospective study, we included the medical records of 324 patients with first episode NMOSD and collected data on clinical parameters. Follow-up extended disability status scale (EDSS) score and relapse rate were analyzed using logistic regression models to determine the independent effect of NLR on outcomes; receiver operating characteristic (ROC) curves were applied to analyze the predictive value of NLR for the prognosis of NMOSD. Interaction and stratification analyses were used to explore the association between NLR and prognosis of patients with NMOSD, and Kaplan-Meier analysis was used to investigate the relationship between NLR and outcome. The association between NLR level with relapse rate and poor recovery was assessed by a Cox regression analysis. Results Patients in the high-NLR group had significantly higher EDSS scores and relapse rates at follow-up (both, P 
ISSN:1471-2377
1471-2377
DOI:10.1186/s12883-021-02432-0