Microbial Transformations of Halolactones and Evaluation of Their Antiproliferative Activity

The microbial transformations of lactones with a halogenoethylocyclohexane moiety were performed in a filamentous fungi culture. The selected, effective biocatalyst for this process was the AM177 strain. The lactones were transformed into the hydroxy derivative, regardless of the type of halogen ato...

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Bibliographic Details
Published in:International journal of molecular sciences 2023-04, Vol.24 (8), p.7587
Main Authors: Mazur, Marcelina, Zych, Karolina Maria, Obmińska-Mrukowicz, Bożena, Pawlak, Aleksandra
Format: Article
Language:English
Subjects:
Absidia glauca
biocatalysis
Biotransformation
Brief Report
Cell Line
cytotoxic activity
Fungi - metabolism
Humans
Lactones
Lactones - chemistry
Lymphoma, T-Cell
microbial hydroxylation
Non-Hodgkin's lymphomas
T cells
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Summary:The microbial transformations of lactones with a halogenoethylocyclohexane moiety were performed in a filamentous fungi culture. The selected, effective biocatalyst for this process was the AM177 strain. The lactones were transformed into the hydroxy derivative, regardless of the type of halogen atom in the substrate structure. For all lactones, the antiproliferative activity was determined toward several cancer cell lines. The antiproliferative potential of halolactones was much broader than that observed for the hydroxyderivative. According to the presented results, the most potent was chlorolactone, which exhibited significant activity toward the T-cell lymphoma line (CL-1) cell line. The hydroxyderivative obtained through biotransformation was not previously described in the literature.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms24087587