Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients

Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus reported to be associated with human prostate cancer and chronic fatigue syndrome. Since retroviruses cause various cancers, and XMRV replication might be facilitated by HIV-1 co-infection, we asked whether certain patients w...

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Bibliographic Details
Published in:Advances in virology 2011-01, Vol.2011 (2011), p.1-4
Main Authors: Chaipan, Chawaree, Delviks-Frankenberry, Krista A., Bagni, Rachel, Wyvill, Kathleen, Yarchoan, Robert, Pathak, Vinay K.
Format: Article
Language:English
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Summary:Xenotropic murine leukemia virus-related virus (XMRV) is a gammaretrovirus reported to be associated with human prostate cancer and chronic fatigue syndrome. Since retroviruses cause various cancers, and XMRV replication might be facilitated by HIV-1 co-infection, we asked whether certain patients with HIV-associated lymphomas are infected with XMRV. Analysis of PMBCs and plasma from 26 patients failed to detect XMRV by PCR, ELISA, or Western blot, suggesting a lack of association between XMRV and AIDS-associated lymphomas.
ISSN:1687-8639
1687-8647
DOI:10.1155/2011/797820