Chikungunya virus antepartum transmission and abnormal infant outcomes in a cohort of pregnant women in Nigeria

• Published in: International journal of infectious diseases 2024-02, Vol.139, p.92-100
• Main Authors: Sagay, Atiene S, Hsieh, Szu-Chia, Dai, Yu-Ching, Chang, Charlotte Ajeong, Ogwuche, Jerry, Ige, Olukemi O, Kahansim, Makshwar L, Chaplin, Beth, Imade, Godwin, Elujoba, Michael, Paul, Michael, Hamel, Donald J, Furuya, Hideki, Khouri, Ricardo, Boaventura, Viviane Sampaio, de Moraes, Laíse, Kanki, Phyllis J, Wang, Wei-Kung
• Format: Article
• Language: English
• Subjects: Africa; Arbovirus; Chikungunya Fever - complications; Chikungunya Fever - diagnosis; Chikungunya Fever - epidemiology; Chikungunya virus; Chikungunya virus - genetics; Cleft Lip - complications; Cleft Palate - complications; Cohort Studies; Congenital abnormality; Dengue; Female; Humans; Immunoglobulin M; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Nigeria - epidemiology; Perinatal transmission; Pregnancy; Pregnant Women; Stillbirth; Zika Virus; Zika Virus Infection - diagnosis; Zika Virus Infection - epidemiology
• ISSN: 1201-9712; 1878-3511
• DOI: 10.1016/j.ijid.2023.11.036

Chikungunya virus (CHIKV), a reemerging global public health concern, which causes acute febrile illness, rash, and arthralgia and may affect both mothers and infants during pregnancy. Mother-to-child transmission (MTCT) of CHIKV in Africa remains understudied. Our cohort study screened 1006 pregnant women with a Zika/dengue/CHIKV rapid test at two clinics in Nigeria between 2019 and 2022. Women who tested positive for the rapid test were followed through their pregnancy and their infants were observed for 6 months, with a subset tested by reverse transcription-polymerase chain reaction (RT-PCR) and neutralization, to investigate seropositivity rates and MTCT of CHIKV. Of the 1006, 119 tested positive for CHIKV immunoglobulin (Ig)M, of which 36 underwent detailed laboratory tests. While none of the IgM reactive samples were RT-PCR positive, 14 symptomatic pregnant women were confirmed by CHIKV neutralization test. Twelve babies were followed with eight normal and four abnormal outcomes, including stillbirth, cleft lip/palate with microcephaly, preterm delivery, polydactyly with sepsis, and jaundice. CHIKV IgM testing identified three possible antepartum transmissions. In Nigeria, we found significant CHIKV infection in pregnancy and possible CHIKV antepartum transmission associated with birth abnormalities.