Body mass index related to executive function and hippocampal subregion volume in subjective cognitive decline

Objective: The present study aims to explore whether Body Mass Index (BMI) level affects the executive function and hippocampal subregions volume of subjective cognitive decline (SCD). Method: A total of 111 participants were included in the analysis, including SCD (38 of normal BMI, 27 of overweigh...

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Published in:Frontiers in aging neuroscience 2022-08, Vol.14, p.905035-905035
Main Authors: Chen, Ruilin, Cai, Guiyan, Xu, Shurui, Sun, Qianqian, Luo, Jia, Wang, Yajun, Li, Ming, Lin, Hui, Liu, Jiao
Format: Article
Language:English
Subjects:
Alzheimer's disease
Anxiety
Body mass index
Body weight
CA1
Cognition & reasoning
Cognitive ability
Dementia
Executive function
hippocampal subregion
Hippocampus
Hypertension
Informed consent
inhibition control function
Medical imaging
Memory
Neuroimaging
Neuroscience
Obesity
Older people
Overweight
Questionnaires
subjective cognitive decline
Substantia grisea
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Summary:Objective: The present study aims to explore whether Body Mass Index (BMI) level affects the executive function and hippocampal subregions volume of subjective cognitive decline (SCD). Method: A total of 111 participants were included in the analysis, including SCD (38 of normal BMI, 27 of overweight and obesity) and Normal cognitive control (NC) (29 of normal BMI, 17 of overweight and obesity). All subjects underwent the Chinese version of the Stroop Color-Word Test to measure the executive function and a high-resolution 3D T1 structural image acquisition. Two-way ANOVA was used to examine the differences in executive function and gray matter volume in hippocampal subregions under different BMI levels between the SCD and NC. Result: The sub-dimensions of executive function in which different BMI levels interact with SCD and NC include inhibition control function (SCWT C-B reaction time(s): F(1, 104)=5.732, P=0.018), and the hippocampal subregions volume of CA1 (F(1, 99)=8.607, P=0.004), Hippocampal tail (F(1, 99)=4.077, P=0.046) and molecular layer (F(1, 99)=6.309, P=0.014). After correction by Bonferroni method, the population × BMI interaction only had a significant effect on the CA1 (P=0.004). Further analysis found that, the SCWT C-B reaction time of SCD were significantly longer than NC no matter at the normal BMI level (F(1, 104)=4.325, P=0.040) or the high BMI level (F(1, 104)=21.530, P
ISSN:1663-4365
1663-4365
DOI:10.3389/fnagi.2022.905035