A formula for predicting emphysema extent in combined idiopathic pulmonary fibrosis and emphysema

No single pulmonary function test captures the functional effect of emphysema in idiopathic pulmonary fibrosis (IPF). Without experienced radiologists, other methods are needed to determine emphysema extent. Here, we report the development and validation of a formula to predict emphysema extent in p...

Full description

Saved in:
Bibliographic Details
Published in:Respiratory research 2024-01, Vol.25 (1), p.33-33, Article 33
Main Authors: Wells, Athol U, Jacob, Joseph, Sverzellati, Nicola, Cross, Gary, Barnett, Joseph, De Lauretis, Angelo, Antoniou, Katerina, Weycker, Derek, Atwood, Mark, Kirchgaessler, Klaus-Uwe, Cottin, Vincent
Format: Article
Language:English
Subjects:
Automation
Carbon monoxide
Clinical trial cohort
Clinical trials
Complications and side effects
Computed tomography
Development and progression
Diagnosis
Emphysema
Emphysema, Pulmonary
Fibrosis
Hospitals
Interstitial lung disease
Lung diseases
Patients
Pulmonary fibrosis
Pulmonary function test
Pulmonary functions
Radiology
Real-world cohort
Respiratory function
Risk factors
Tomography
Variables
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:No single pulmonary function test captures the functional effect of emphysema in idiopathic pulmonary fibrosis (IPF). Without experienced radiologists, other methods are needed to determine emphysema extent. Here, we report the development and validation of a formula to predict emphysema extent in patients with IPF and emphysema. The development cohort included 76 patients with combined IPF and emphysema at the Royal Brompton Hospital, London, United Kingdom. The formula was derived using stepwise regression to generate the weighted combination of pulmonary function data that fitted best with emphysema extent on high-resolution computed tomography. Test cohorts included patients from two clinical trials (n = 455 [n = 174 with emphysema]; NCT00047645, NCT00075998) and a real-world cohort from the Royal Brompton Hospital (n = 191 [n = 110 with emphysema]). The formula is only applicable for patients with IPF and concomitant emphysema and accordingly was not used to detect the presence or absence of emphysema. The formula was: predicted emphysema extent = 12.67 + (0.92 x percent predicted forced vital capacity) - (0.65 x percent predicted forced expiratory volume in 1 second) - (0.52 x percent predicted carbon monoxide diffusing capacity). A significant relationship between the formula and observed emphysema extent was found in both cohorts (R  = 0.25, P 
ISSN:1465-993X
1465-9921
1465-993X
1465-9921
DOI:10.1186/s12931-023-02589-x