Brown Algae Padina sanctae-crucis Børgesen: A Potential Nutraceutical

• Published in: Marine drugs 2017-09, Vol.15 (10), p.251
• Main Authors: Nogueira, Raquel B S S, Tomaz, Anna Cláudia A, Pessoa, Déborah R, Xavier, Aline L, Pita, João Carlos L R, Sobral, Marianna V, Pontes, Marcela L C, Pessôa, Hilzeth L F, Diniz, Margareth F F M, Miranda, George Emmanuel C, Vieira, Maria Aparecida R, Marques, Marcia O M, Souza, Maria de Fátima V, Cunha, Emídio V L
• Format: Article
• Language: English
• Subjects: Acute toxicity; Algae; alpha-Linolenic Acid - pharmacology; Animals; Antioxidants; Antioxidants - pharmacology; Bioactive compounds; Biocompatibility; Biological activity; Biological Products - chemistry; Biological Products - pharmacology; Cytotoxicity; Dictyotaceae; Dietary Supplements; dolastane diterpene; Erythrocytes; Erythrocytes - drug effects; Fatty acids; Fatty Acids - pharmacology; Fatty Acids, Unsaturated - pharmacology; Female; Functional foods & nutraceuticals; Genotoxicity; Humans; Linolenic acid; Male; Mannitol; Methanol - chemistry; Mice; Mutagenicity Tests - methods; Nutrition; palmitic acid; Palmitic Acid - pharmacology; Phaeophyceae - chemistry; Phaeophytin; Toxicity; Tropical climate
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md15100251

Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus ; phaeophytin and hidroxy-phaeophytin new for the family Dictyotaceae, and; mannitol first described in this species. Saturated fatty acids as compared to the percentages of unsaturated fatty acids were shown to be present in greater abundance. Palmitic and linolenic acid were the main saturated and unsaturated acids, respectively. Cytotoxic and antioxidant activities were evaluated using human erythrocytes. In vivo evaluations of acute toxicity and genotoxicity were performed in mice. Methanolic extract of presented antioxidant activity and did not induce cytotoxicity, genotoxicity or acute toxicity. Since is already used as food, has essential fatty acids for the nutrition of mammals, does not present toxicity and has antioxidant activity, it can be considered as a potential nutraceutical.