Measurements of peri-prostatic adipose tissue by MRI predict bone metastasis in patients with newly diagnosed prostate cancer

To investigate the role of MRI measurements of peri-prostatic adipose tissue (PPAT) in predicting bone metastasis (BM) in patients with newly diagnosed prostate cancer (PCa). We performed a retrospective study on 156 patients newly diagnosed with PCa by prostate biopsy between October 2010 and Novem...

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Bibliographic Details
Published in:Frontiers in oncology 2024, Vol.14, p.1393650-1393650
Main Authors: Liu, Bo-Hao, Mao, Yun-Hua, Li, Xiao-Yang, Luo, Rui-Xiang, Zhu, Wei-An, Su, Hua-Bin, Zeng, Heng-Da, Chen, Chu-Hao, Zhao, Xiao, Zou, Chen, Luo, Yun
Format: Article
Language:English
Subjects:
metastasis
MRI
nomogram
peri-prostatic adipose tissue
prostate cancer
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Summary:To investigate the role of MRI measurements of peri-prostatic adipose tissue (PPAT) in predicting bone metastasis (BM) in patients with newly diagnosed prostate cancer (PCa). We performed a retrospective study on 156 patients newly diagnosed with PCa by prostate biopsy between October 2010 and November 2022. Clinicopathologic characteristics were collected. Measurements including PPAT volume and prostate volume were calculated by MRI, and the normalized PPAT (PPAT volume/prostate volume) was computed. Independent predictors of BM were determined by univariate and multivariate logistic regression analysis, and a new nomogram was developed based on the predictors. Receiver operating characteristic (ROC) curves were used to estimate predictive performance. PPAT and normalized PPAT were associated with BM (P
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2024.1393650