Frailty in kidney transplant candidates and recipients: pathogenesis and intervention strategies

With the rapid aging of the global population posing a serious problem, frailty, a non-specific state that reflects physiological senescence rather than aging in time, has become more widely addressed by researchers in various medical fields. A high prevalence of frailty is found among kidney transp...

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Bibliographic Details
Published in:Chinese medical journal 2023-05, Vol.136 (9), p.1026-1036
Main Authors: Cao, Huawei, Zhang, Jiandong, Sun, Zejia, Wu, Jiyue, Hao, Changzhen, Wang, Wei
Format: Article
Language:English
Subjects:
Aging
Cognitive ability
Cohort analysis
Cross-Sectional Studies
Epidemiology
Frailty
Frailty - epidemiology
Humans
Immune system
Kidney Failure, Chronic
Kidney Transplantation - adverse effects
Kidney transplants
Medical prognosis
Mortality
Musculoskeletal system
Pathogenesis
Physiology
Quality of Life
Review
Risk Factors
Transplant Recipients
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Summary:With the rapid aging of the global population posing a serious problem, frailty, a non-specific state that reflects physiological senescence rather than aging in time, has become more widely addressed by researchers in various medical fields. A high prevalence of frailty is found among kidney transplant (KT) candidates and recipients. Therefore, their frailty has become a research hotspot in the field of transplantation. However, current studies mainly focus on the cross-sectional survey of the incidence of frailty among KT candidates and recipients and the relationship between frailty and transplantation. Research on the pathogenesis and intervention is scattered, and relevant review literature is scarce. Exploring the pathogenesis of frailty in KT candidates and recipients and determining effective intervention measures may reduce waiting list mortality and improve the long-term quality of life of KT recipients. Therefore, this review explains the pathogenesis and intervention measures for frailty in KT candidates and recipients to provide a reference for the formulation of effective intervention strategies.
ISSN:0366-6999
2542-5641
2542-5641
DOI:10.1097/CM9.0000000000002312