Congenital Zika syndrome: association between the gestational trimester of maternal infection, severity of brain computed tomography findings and microcephaly at birth

This study analyzed possible associations between the trimester of maternal Zika virus infection (ZIKV) in pregnancy, severity of brain computed tomography (CT) findings and the presence of microcephaly at birth in children with Congenital Zika Syndrome (CZS). It was an analytical study in a cohort...

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Published in:Revista do Instituto de Medicina Tropical de São Paulo 2020-01, Vol.62, p.1-8
Main Authors: Mendes, Ana Karolina Torres, Ribeiro, Marizélia Rodrigues Costa, Lamy-Filho, Fernando, Amaral, Gláucio Andrade, Borges, Marcella Costa Ribeiro, Costa, Luciana Cavalcante, Cavalcante, Tamires Barradas, Batista, Rosângela Fernandes Lucena, Sousa, Patrícia da Silva, Silva, Antônio Augusto Moura da
Format: Article
Language:English
Subjects:
Brain computed tomography
Congenital abnormalities
Microcephaly
Original
TROPICAL MEDICINE
Zika virus
Zika virus infection
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Summary:This study analyzed possible associations between the trimester of maternal Zika virus infection (ZIKV) in pregnancy, severity of brain computed tomography (CT) findings and the presence of microcephaly at birth in children with Congenital Zika Syndrome (CZS). It was an analytical study in a cohort of children with CZS. Symptoms of maternal infection were dichotomized into the 1 st trimester of pregnancy and other trimesters. Head circumference (HC) at birth was used to calculate the z-score. Mild microcephaly was defined as HC between 2 and ≥3 standard deviations (SD) below the mean for each gestational age and sex, and severe microcephaly when HC
ISSN:1678-9946
0036-4665
1678-9946
DOI:10.1590/s1678-9946202062056