Fucoidan Characterization: Determination of Purity and Physicochemical and Chemical Properties

Fucoidans are marine sulfated biopolysaccharides that have heterogenous and complicated chemical structures. Various sugar monomers, glycosidic linkages, molecular masses, branching sites, and sulfate ester pattern and content are involved within their backbones. Additionally, sources, downstream pr...

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Bibliographic Details
Published in:Marine drugs 2020-11, Vol.18 (11), p.571
Main Authors: Zayed, Ahmed, El-Aasr, Mona, Ibrahim, Abdel-Rahim S, Ulber, Roland
Format: Article
Language:English
Subjects:
Acids
Algae
Anticoagulants
Chemical properties
Chemicophysical properties
Chemistry
Fucoidan
fucoidanases
fucoidans
glycosidic linkages
Industrial applications
Linkages
Methods
molecular masses
Molecular Structure
Molecular Weight
Monomers
NMR
Polymers
Polysaccharides - chemistry
Polysaccharides - isolation & purification
Polysaccharides - pharmacology
Purity
Review
Saccharides
Spectrometry
Structure-Activity Relationship
structure–activity relationships
Sulfation
Tumors
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Summary:Fucoidans are marine sulfated biopolysaccharides that have heterogenous and complicated chemical structures. Various sugar monomers, glycosidic linkages, molecular masses, branching sites, and sulfate ester pattern and content are involved within their backbones. Additionally, sources, downstream processes, and geographical and seasonal factors show potential effects on fucoidan structural characteristics. These characteristics are documented to be highly related to fucoidan potential activities. Therefore, numerous chemical qualitative and quantitative determinations and structural elucidation methods are conducted to characterize fucoidans regarding their physicochemical and chemical features. Characterization of fucoidan polymers is considered a bottleneck for further biological and industrial applications. Consequently, the obtained results may be related to different activities, which could be improved afterward by further functional modifications. The current article highlights the different spectrometric and nonspectrometric methods applied for the characterization of native fucoidans, including degree of purity, sugar monomeric composition, sulfation pattern and content, molecular mass, and glycosidic linkages.
ISSN:1660-3397
1660-3397
DOI:10.3390/md18110571