Impact of marital status on overall survival in patients with early-stage hepatocellular carcinoma

• Published in: Scientific reports 2022-11, Vol.12 (1), p.19923-19923, Article 19923
• Main Authors: Chen, Fangjie, Wu, Ying, Xu, Hong’en, Song, Tao, Yan, Senxiang
• Format: Article
• Language: English
• Subjects: 631/67; 692/308; 692/4020; 692/4028; 692/499; Carcinoma, Hepatocellular - pathology; Diagnosis; Epidemiology; Hepatocellular carcinoma; Humanities and Social Sciences; Humans; Kaplan-Meier Estimate; Liver cancer; Liver Neoplasms - pathology; Marital Status; Medical prognosis; multidisciplinary; Patients; Science; Science (multidisciplinary); SEER Program; Survival; Tumors
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-14120-1

The purpose of the present research was to assess the prognostic impact of marital status in hepatocellular carcinoma (HCC) patients with tumors ≤ 2 cm (stage Ia) based on the data from the Surveillance, Epidemiology, and End Results (SEER) database. Patients who received a histopathologic HCC diagnosis between 2004 and 2016 were recruited. Overall survival (OS) was the major outcome measure. The Cox regression model and the Fine-Gray regression model were used for the purpose of comparing and examining the prognostic value of marital status for OS. The data for a total of 2446 stage Ia HCC patients were extracted from the database. The median overall survival time was 96.0 months, with 5-year and 10-year overall survival rates of 58.2% and 45.8%, respectively. In both the Fine-Gray regression model and Cox regression model, marital status [married vs. unmarried and others, both P