Humoral Response to Anopheles maculatus and Anopheles sundaicus Salivary Gland Proteins

The salivary gland of female Anopheles mosquito has important role in malaria transmission by salivary proteins that enhancing Plasmodium transmission. The mosquito saliva contains vasomodulatory and immunomodulatory components that inhibit the physiological response of the host. Therefore, the path...

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Bibliographic Details
Published in:Journal of Agromedicine and Medical Sciences (AMS) 2017-07, Vol.3 (2), p.53-61
Main Authors: Armiyanti, Yunita, Widodo, Widodo, Fitri, Loeki Enggar, Sardjono, Teguh Wahju
Format: Article
Language:English
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Summary:The salivary gland of female Anopheles mosquito has important role in malaria transmission by salivary proteins that enhancing Plasmodium transmission. The mosquito saliva contains vasomodulatory and immunomodulatory components that inhibit the physiological response of the host. Therefore, the pathogen infects the host without any resistance. The salivary proteins also induce the production of antibody IgG in the host after exposed by the Anopheles mosquito bites repeatedly. This study aims to measured the antibody response of inhabitants living in malaria endemic areas (Kalirejo viilages, Kokap, Kulonprogo) to salivary gland proteins of An. maculatus and An.sundaicus. The level of antibody response was measured by ELISA and analyzed with T test or Anova test for normal distribution of data and Mann Whitney test or Kruskal Wallis test for the data were not normally distributed. The result showed that the level of anti-salivary gland homogenate IgG from sera of people living in malaria endemic area was significantly higher than people living in non-malaria endemic area and negative control (p
ISSN:2460-9048
2460-9048
2714-5654
DOI:10.19184/ams.v3i2.5071