Association of lamina cribrosa thickness and hippocampal volume in Alzheimer's disease patients

• Published in: Arquivos de neuro-psiquiatria 2024-11, Vol.82 (11), p.1-7
• Main Authors: Ulusoy, Ersin Kasım, Ulusoy, Döndü Melek, Göl, Mehmet Fatih, Çiçek, Ayşe, Tokmak, Turgut Tursem
• Format: Article
• Language: English
• Subjects: Aged; Alzheimer Disease; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - pathology; Analysis of Variance; Case-Control Studies; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - pathology; Doença de Alzheimer; Espessura da Lâmina Cribrosa; Female; Hippocampal Volume; Hippocampus - diagnostic imaging; Hippocampus - pathology; Humans; Lamina Cribrosa Thickness; Magnetic Resonance Imaging; Male; Middle Aged; NEUROSCIENCES; Organ Size; Original; PSYCHIATRY; Reference Values; Tomography, Optical Coherence - methods; Volume do Hipocampo
• ISSN: 0004-282X; 1678-4227; 1678-4227
• DOI: 10.1055/s-0044-1791658

Alzheimer's disease (AD) is the most common cause of dementia and affects a large portion of the elderly population worldwide.  To analyze the relationship between lamina cribrosa thickness (LCT) and hippocampal volume in patients with AD and mild cognitive impairment (MCI).  The sample in the present study consisted of 20 recently diagnosed MCI patients, 20 recently diagnosed AD patients, and 20 matched healthy volunteers. Every patient underwent magnetic resonance imaging (MRI) scans. The VolBrain software (open-access platform for MRI brain analysis) was used to calculate the hippocampal volume. Optical coherence tomography was performed to measure the LCT. Analysis of variance and Pearson chi-squared tests were employed to assess the results.  The lowest total hippocampal volume (