Cellular Prion Protein Is Closely Associated with Early Recurrence and Poor Survival in Patients with Hepatocellular Carcinoma

The cellular prion protein (PrP ) is known to play a role in cancer proliferation and metastasis. However, the role of PrP expression in hepatocellular carcinoma (HCC) is unknown. This study investigated whether overexpression of PrP affects recurrence after surgical resection and survival in HCC. A...

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Bibliographic Details
Published in:Diagnostics (Basel) 2022-07, Vol.12 (7), p.1635
Main Authors: Kim, Mo-Jong, Cho, Yoon-Ah, Kim, Eunhye, Choe, Ji-Young, Park, Ji-Won, Lee, Junyong, Lee, Jung-Woo, Moon, Sung-Hoon, Kim, Yong-Sun, Kim, Sung-Eun, Choi, Eun-Kyoung
Format: Article
Language:English
Subjects:
Antibodies
Cancer therapies
hepatic resection
Hepatitis
hepatocellular carcinoma
Hospitals
Kinases
Liver cancer
Medical prognosis
prion protein
Proteins
recurrence
Software
Surgery
survival
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Summary:The cellular prion protein (PrP ) is known to play a role in cancer proliferation and metastasis. However, the role of PrP expression in hepatocellular carcinoma (HCC) is unknown. This study investigated whether overexpression of PrP affects recurrence after surgical resection and survival in HCC. A total of 110 HCC patients who underwent hepatic resection were included. They were followed up for a median of 42 months (range 1-213 months) after hepatectomy. The relationships between PrP expression and the HCC histologic features, recurrence of HCC following surgical resection, and survival of the patients were examined. Seventy-one cases (64.5%) of HCC demonstrated higher expression of PrP . The expression of PrP was only correlated with diabetes mellitus. There was no association between PrP expression and age, sex, hypertension, hepatitis B virus positivity, alcohol consumption, Child-Pugh class, major portal vein invasion, serum alpha-fetoprotein, and HCC size or number. The 1-year recurrence rates in patients with higher PrP expression were higher than those with lower PrP expression. The cumulative survival rates of patients with higher PrP expression were significantly shorter than those of patients with lower PrP expression. In conclusion, PrP expression is closely associated with early recurrence and poor survival of HCC patients following surgical resection.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12071635