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Roles of C/EBP class bZip proteins in the growth and cell competition of Rp ('Minute') mutants in Drosophila
Reduced copy number of ribosomal protein ( ) genes adversely affects both flies and mammals. encodes a reportedly -specific AT-hook, bZIP protein responsible for many of the effects including the elimination of mutant cells by competition with wild type cells. Irbp18, an evolutionarily conserved bZI...
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| Published in: | eLife 2020-01, Vol.9 |
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| creator | Blanco, Jorge Cooper, Jacob C Baker, Nicholas E |
| description | Reduced copy number of ribosomal protein (
) genes adversely affects both flies and mammals.
encodes a reportedly
-specific AT-hook, bZIP protein responsible for many of the effects including the elimination of
mutant cells by competition with wild type cells. Irbp18, an evolutionarily conserved bZIP gene, heterodimerizes with Xrp1 and with another bZip protein, dATF4. We show that Irbp18 is required for the effects of Xrp1, whereas dATF4 does not share the same phenotype, indicating that Xrp1/Irbp18 is the complex active in
mutant cells, independently of other complexes that share Irbp18. Xrp1 and Irbp18 transcripts and proteins are upregulated in
mutant cells by auto-regulatory expression that depends on the Xrp1 DNA binding domains and is necessary for cell competition. We show that Xrp1 is conserved beyond
, although under positive selection for rapid evolution, and that at least one human bZip protein can similarly affect
development. |
| doi_str_mv | 10.7554/eLife.50535 |
| format | article |
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) genes adversely affects both flies and mammals.
encodes a reportedly
-specific AT-hook, bZIP protein responsible for many of the effects including the elimination of
mutant cells by competition with wild type cells. Irbp18, an evolutionarily conserved bZIP gene, heterodimerizes with Xrp1 and with another bZip protein, dATF4. We show that Irbp18 is required for the effects of Xrp1, whereas dATF4 does not share the same phenotype, indicating that Xrp1/Irbp18 is the complex active in
mutant cells, independently of other complexes that share Irbp18. Xrp1 and Irbp18 transcripts and proteins are upregulated in
mutant cells by auto-regulatory expression that depends on the Xrp1 DNA binding domains and is necessary for cell competition. We show that Xrp1 is conserved beyond
, although under positive selection for rapid evolution, and that at least one human bZip protein can similarly affect
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) genes adversely affects both flies and mammals.
encodes a reportedly
-specific AT-hook, bZIP protein responsible for many of the effects including the elimination of
mutant cells by competition with wild type cells. Irbp18, an evolutionarily conserved bZIP gene, heterodimerizes with Xrp1 and with another bZip protein, dATF4. We show that Irbp18 is required for the effects of Xrp1, whereas dATF4 does not share the same phenotype, indicating that Xrp1/Irbp18 is the complex active in
mutant cells, independently of other complexes that share Irbp18. Xrp1 and Irbp18 transcripts and proteins are upregulated in
mutant cells by auto-regulatory expression that depends on the Xrp1 DNA binding domains and is necessary for cell competition. We show that Xrp1 is conserved beyond
, although under positive selection for rapid evolution, and that at least one human bZip protein can similarly affect
development.</description><subject>Apoptosis</subject><subject>bZip domain</subject><subject>c/ebp</subject><subject>CCAAT/enhancer-binding protein</subject><subject>cell competition</subject><subject>Cell cycle</subject><subject>Cloning</subject><subject>Competition</subject><subject>Competitive advantage</subject><subject>Copy number</subject><subject>Deoxyribonucleic acid</subject><subject>Developmental Biology</subject><subject>DNA</subject><subject>Drosophila</subject><subject>Gene expression</subject><subject>growth control</subject><subject>Insects</subject><subject>Mammals</subject><subject>Mutants</subject><subject>Mutation</subject><subject>Phenotypes</subject><subject>Positive selection</subject><subject>Proteins</subject><subject>ribosomal protein</subject><subject>xrp1</subject><issn>2050-084X</issn><issn>2050-084X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNpdkl1rFDEYhYMotqy98l4CXrQi2yaTr8lNQdeqhRWlKIg3IZNkdrPMJmOSUfz3ZndraQ0hCcnzHt4cDgDPMToXjNELt_S9O2eIEfYIHDeIoTlq6ffH985H4CTnDapD0LbF8ik4IlgiKTA9BsNNHFyGsYeLi6u3X6AZdM6w--FHOKZYnA8Z-gDL2sFVir_LGupgoXHDAE3cjq744mPY1d-M8Oz0kw9Tcaev4HYqOpR97bsUcxzXftDPwJNeD9md3O4z8O391dfFx_ny84frxZvl3DCKS105okh0nWspZ1KblmnXI04sdoiJTrC-QUgLI42VzFJB2jopN61hjDeczMD1QddGvVFj8lud_qiovdpfxLRSOhVvBqcMFZRpwXsmELWEtdYKiXrckb6xxMmqdXnQGqdu66xxoSQ9PBB9-BL8Wq3iL8Ul5RThKnB2K5Diz8nlorY-7wzUwcUpq4YQ2jSIC1LRl_-hmzilUK2qFJWYU1o_OwOvD5Spxubk-rtmMFK7UKh9KNQ-FJV-cb__O_ZfBMhfOKGw8Q</recordid><startdate>20200107</startdate><enddate>20200107</enddate><creator>Blanco, Jorge</creator><creator>Cooper, Jacob C</creator><creator>Baker, Nicholas E</creator><general>eLife Sciences Publications Ltd</general><general>eLife Sciences Publications, Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-4250-3488</orcidid></search><sort><creationdate>20200107</creationdate><title>Roles of C/EBP class bZip proteins in the growth and cell competition of Rp ('Minute') mutants in Drosophila</title><author>Blanco, Jorge ; Cooper, Jacob C ; Baker, Nicholas E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-c560407bbe84659ac85aef063d1e057b75f200a7c9cd95d473873846c8c556263</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Apoptosis</topic><topic>bZip domain</topic><topic>c/ebp</topic><topic>CCAAT/enhancer-binding protein</topic><topic>cell competition</topic><topic>Cell cycle</topic><topic>Cloning</topic><topic>Competition</topic><topic>Competitive advantage</topic><topic>Copy number</topic><topic>Deoxyribonucleic acid</topic><topic>Developmental Biology</topic><topic>DNA</topic><topic>Drosophila</topic><topic>Gene expression</topic><topic>growth control</topic><topic>Insects</topic><topic>Mammals</topic><topic>Mutants</topic><topic>Mutation</topic><topic>Phenotypes</topic><topic>Positive selection</topic><topic>Proteins</topic><topic>ribosomal protein</topic><topic>xrp1</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blanco, Jorge</creatorcontrib><creatorcontrib>Cooper, Jacob C</creatorcontrib><creatorcontrib>Baker, Nicholas E</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>eLife</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blanco, Jorge</au><au>Cooper, Jacob C</au><au>Baker, Nicholas E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Roles of C/EBP class bZip proteins in the growth and cell competition of Rp ('Minute') mutants in Drosophila</atitle><jtitle>eLife</jtitle><addtitle>Elife</addtitle><date>2020-01-07</date><risdate>2020</risdate><volume>9</volume><issn>2050-084X</issn><eissn>2050-084X</eissn><abstract>Reduced copy number of ribosomal protein (
) genes adversely affects both flies and mammals.
encodes a reportedly
-specific AT-hook, bZIP protein responsible for many of the effects including the elimination of
mutant cells by competition with wild type cells. Irbp18, an evolutionarily conserved bZIP gene, heterodimerizes with Xrp1 and with another bZip protein, dATF4. We show that Irbp18 is required for the effects of Xrp1, whereas dATF4 does not share the same phenotype, indicating that Xrp1/Irbp18 is the complex active in
mutant cells, independently of other complexes that share Irbp18. Xrp1 and Irbp18 transcripts and proteins are upregulated in
mutant cells by auto-regulatory expression that depends on the Xrp1 DNA binding domains and is necessary for cell competition. We show that Xrp1 is conserved beyond
, although under positive selection for rapid evolution, and that at least one human bZip protein can similarly affect
development.</abstract><cop>England</cop><pub>eLife Sciences Publications Ltd</pub><pmid>31909714</pmid><doi>10.7554/eLife.50535</doi><orcidid>https://orcid.org/0000-0002-4250-3488</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Publicly Available Content Database; PubMed Central |
| subjects | Apoptosis bZip domain c/ebp CCAAT/enhancer-binding protein cell competition Cell cycle Cloning Competition Competitive advantage Copy number Deoxyribonucleic acid Developmental Biology DNA Drosophila Gene expression growth control Insects Mammals Mutants Mutation Phenotypes Positive selection Proteins ribosomal protein xrp1 |
| title | Roles of C/EBP class bZip proteins in the growth and cell competition of Rp ('Minute') mutants in Drosophila |
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