Peripheral neuropathy in patients with multiple sclerosis

To determine the prevalence and severity of neuropathic pain, sudomotor dysfunction and abnormal vibration perception in patients with MS. 73 patients with MS and 32 age-matched healthy controls underwent assessment of expanded disability severity score (EDSS), DN4 to assess neuropathic pain, electr...

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Bibliographic Details
Published in:PloS one 2018-03, Vol.13 (3), p.e0193270-e0193270
Main Authors: Khan, Adnan, Kamran, Saadat, Ponirakis, Georgios, Akhtar, Naveed, Khan, Rabia, George, Pooja, Babu, Blessy M, Ibrahim, Faiza M, Petropoulos, Ioannis N, Canibano, Beatriz G, Wilins, Stacy S, Deleu, Dirk, Shuaib, Ashfaq, Malik, Rayaz A
Format: Article
Language:English
Subjects:
Adult
Biology and Life Sciences
Care and treatment
Development and progression
Disability Evaluation
Female
Galvanic Skin Response
Humans
Male
Medicine and Health Sciences
Multiple sclerosis
Multiple Sclerosis - complications
Multiple Sclerosis - epidemiology
Multiple Sclerosis - physiopathology
Neuralgia - complications
Neuralgia - epidemiology
Neuralgia - physiopathology
Peripheral Nervous System Diseases - complications
Peripheral Nervous System Diseases - epidemiology
Peripheral Nervous System Diseases - physiopathology
Physical Sciences
Prevalence
Prevalence studies (Epidemiology)
Sensory Thresholds
Severity of Illness Index
Social Sciences
Vibration
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Summary:To determine the prevalence and severity of neuropathic pain, sudomotor dysfunction and abnormal vibration perception in patients with MS. 73 patients with MS and 32 age-matched healthy controls underwent assessment of expanded disability severity score (EDSS), DN4 to assess neuropathic pain, electrochemical skin conductance (ESC) to assess sudomotor function and vibration perception threshold (VPT). Patients with MS had a higher DN4 score (p < 0.001) with 14% fulfilling the criteria for neuropathic pain elevated VPT (p < 0.001) and lower ESC on the feet (p < 0.001) and hands (p < 0.001) compared to control participants. ESC on the feet (32% of MS patients) and hands (30% of MS patients) were lower, and DN4 (77% of MS patients) and VPT (64% of MS patients) were greater than 2SD of the healthy control values, respectively. EDSS correlated with the number of relapses (r = 0.564, p < 0.001), VPT (r = -0.457, < 0.001) and ESC on the feet (r = -0.268, p = 0.023). Patients with multiple sclerosis have evidence of sudomotor dysfunction and elevated vibration perception, which were associated with neurological disability from MS.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0193270