IFIT3 Is Increased in Serum from Patients with Chronic Hepatitis B Virus (HBV) Infection and Promotes the Anti-HBV Effect of Interferon Alpha via JAK-STAT2 In Vitro

Increasing evidence indicates that interferon alpha (IFN-α) therapy is an effective treatment option for a subgroup of patients with chronic hepatitis B virus (HBV) infection. It has been confirmed that interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), a member of the interferon-s...

Full description

Saved in:
Bibliographic Details
Published in:Microbiology spectrum 2022-12, Vol.10 (6), p.e0155722-e0155722
Main Authors: Xu, Siyi, Huang, Jinlan, Xun, Zhen, Li, Shiqi, Fu, Ya, Lin, Ni, Wu, Wennan, Chen, Tianbin, Liu, Can, Ou, Qishui
Format: Article
Language:English
Subjects:
Antiviral Agents - pharmacology
Antiviral Agents - therapeutic use
chronic hepatitis B
Hepatitis B
Hepatitis B Surface Antigens
Hepatitis B virus - genetics
Hepatitis B, Chronic - drug therapy
Humans
IFIT3
interferon
Interferon-alpha - metabolism
Interferon-alpha - pharmacology
Intracellular Signaling Peptides and Proteins - metabolism
Intracellular Signaling Peptides and Proteins - pharmacology
Janus Kinases - metabolism
Janus Kinases - pharmacology
Molecular and Cellular Biology
Research Article
RNA, Messenger
Signal Transduction
STAT Transcription Factors - metabolism
STAT Transcription Factors - pharmacology
STAT2 Transcription Factor - metabolism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Increasing evidence indicates that interferon alpha (IFN-α) therapy is an effective treatment option for a subgroup of patients with chronic hepatitis B virus (HBV) infection. It has been confirmed that interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), a member of the interferon-stimulated genes (ISGs), could inhibit the replication of various viruses. However, its effect on HBV replication is unclear. The present study sought to explore the role and mechanism of IFIT3 in IFN-α antiviral activities against HBV. IFIT3 mRNA levels in the peripheral blood of 108 treatment-naive patients and 70 healthy controls were analyzed first. The effect of IFIT3 on the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway under the dual intervention of IFN-α and HBV was also explored . Treatment-naive individuals exhibited elevated levels of IFIT3 mRNA compared to the controls (  
ISSN:2165-0497
2165-0497
DOI:10.1128/spectrum.01557-22