Zinc Oxide Nanoparticles Induce DNA Damage in Sand Dollar Scaphechinus mirabilis Sperm

Products containing nanomaterials are becoming more and more common in everyday life. Zinc oxide nanoparticles (ZnO NPs), meanwhile, are among the most widely used NPs. However, their genotoxic effect on the germ products of marine organisms is poorly understood. Therefore, the effects of ZnO NPs an...

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Bibliographic Details
Published in:Toxics (Basel) 2022-06, Vol.10 (7), p.348
Main Authors: Kukla, Sergey Petrovich, Chelomin, Victor Pavlovich, Mazur, Andrey Alexandrovich, Slobodskova, Valentina Vladimirovna
Format: Article
Language:English
Subjects:
Animal reproduction
Bioassays
Comet assay
Cosmetics
Damage detection
Deoxyribonucleic acid
DNA
DNA damage
Experiments
Gene expression
Genomes
Genotoxicity
Ions
Laboratories
Males
Marine organisms
Nanomaterials
Nanoparticles
Nanotechnology
Organisms
Pollutants
Sand
Scaphechinus mirabilis
Sperm
Zinc oxide
Zinc oxides
ZnO NPs
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Summary:Products containing nanomaterials are becoming more and more common in everyday life. Zinc oxide nanoparticles (ZnO NPs), meanwhile, are among the most widely used NPs. However, their genotoxic effect on the germ products of marine organisms is poorly understood. Therefore, the effects of ZnO NPs and zinc ions (20, 50, 100, 200 µg/L) on the sperm of sand dollar Scaphechinus mirabilis were compared. Comet assay showed that both tested pollutants caused an increase in DNA damage to 6.57 ± 2.41 and 7.42 ± 0.88% DNA in the comet tail, for zinc ions and ZnO NPs, respectively. Additionally, a different pattern was shown by the increase in DNA damage, with increasing concentration of pollutants, in different experimental groups.
ISSN:2305-6304
2305-6304
DOI:10.3390/toxics10070348