The Skin Microbiome in Cutaneous T-Cell Lymphomas (CTCL)—A Narrative Review

In recent years, numerous studies have shown a significant role of the skin microbiome in the development and exacerbation of skin diseases. Cutaneous T-cell lymphomas (CTCL) are a group of malignancies primary involving skin, with unclear pathogenesis and etiology. As external triggers appear to co...

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Bibliographic Details
Published in:Pathogens (Basel) 2022-08, Vol.11 (8), p.935
Main Authors: Łyko, Magdalena, Jankowska-Konsur, Alina
Format: Article
Language:English
Subjects:
Acne
Antigens
Antimicrobial agents
Atopic dermatitis
Bacteria
Chemokines
Composition
Cutaneous T cell lymphoma
Dermatitis
Development and progression
Diagnosis
Dysbacteriosis
Etiology
Fungi
Health aspects
Immune system
Inflammation
Lymphocytes T
Lymphoma
Microbiomes
Microbiota
Microbiota (Symbiotic organisms)
Microorganisms
mycosis fungoides
Pathogenesis
Pathogens
Peptides
Pruritus
Psoriasis
Review
Risk factors
Skin diseases
skin microbiome
Staphylococcus aureus
Sézary syndrome
T-cell lymphoma
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Summary:In recent years, numerous studies have shown a significant role of the skin microbiome in the development and exacerbation of skin diseases. Cutaneous T-cell lymphomas (CTCL) are a group of malignancies primary involving skin, with unclear pathogenesis and etiology. As external triggers appear to contribute to chronic skin inflammation and the malignant transformation of T-cells, some microorganisms or dysbiosis may be involved in these processes. Recently, studies analyzing the skin microbiome composition and diversity have been willingly conducted in CTCL patients. In this review, we summarize currently available data on the skin microbiome in CTLC. We refer to a healthy skin microbiome and the contribution of microorganisms in the pathogenesis and progression of other skin diseases, focusing on atopic dermatitis and its similarities to CTCL. Moreover, we present information about the possible role of identified microorganisms in CTCL development and progression. Additionally, we summarize information about the involvement of Staphylococcus aureus in CTCL pathogenesis. This article also presents therapeutic options used in CTCL and discusses how they may influence the microbiome.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens11080935