A refractory heterogeneous Cryopyrin-Associated Periodic Syndrome (CAPS) phenotype related to V198M mutation responds to canakinumab - a case report

Conclusion Based on our experience in this patient and a review of literature on efficacy of IL-1 inhibition in CAPS patients with V198M mutation, high dose canakinumab i.v* with increased dosing frequency yields symptomatic relief without evidence of increased AE.

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Published in:Pediatric Rheumatology 2011-09, Vol.9 (S1), p.P9-P9, Article P9
Main Authors: Hansmann, Sandra, Zimmer, Christiane, Moll, Monika, Rieber, Nikolaus, Kuemmerle-Deschner, Jasmin B
Format: Article
Language:English
Subjects:
Genotype & phenotype
Infections
Mutation
Pediatrics
Poster Presentation
Rheumatology
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container_end_page P9
container_issue S1
container_start_page P9
container_title Pediatric Rheumatology
container_volume 9
creator Hansmann, Sandra
Zimmer, Christiane
Moll, Monika
Rieber, Nikolaus
Kuemmerle-Deschner, Jasmin B
description Conclusion Based on our experience in this patient and a review of literature on efficacy of IL-1 inhibition in CAPS patients with V198M mutation, high dose canakinumab i.v* with increased dosing frequency yields symptomatic relief without evidence of increased AE.
doi_str_mv 10.1186/1546-0096-9-S1-P9
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subjects Genotype & phenotype
Infections
Mutation
Pediatrics
Poster Presentation
Rheumatology
title A refractory heterogeneous Cryopyrin-Associated Periodic Syndrome (CAPS) phenotype related to V198M mutation responds to canakinumab - a case report
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