Effect of TB Treatment on Neutrophil-Derived Soluble Inflammatory Mediators in TB Patients with and without HIV Coinfection

The mycobacteriological analysis of sputum samples is the gold standard for tuberculosis diagnosis and treatment monitoring. However, sputum production can be challenging after the initiation of TB treatment. As a possible alternative, we therefore investigated the dynamics of neutrophil-derived sol...

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Bibliographic Details
Published in:Pathogens (Basel) 2023-06, Vol.12 (6), p.794
Main Authors: Sitoe, Nádia, Chelene, Imelda, Ligeiro, Sofia, Castiano, Celso, Ahmed, Mohamed I M, Held, Kathrin, Nhassengo, Pedroso, Khosa, Celso, Matavele-Chissumba, Raquel, Hoelscher, Michael, Rachow, Andrea, Geldmacher, Christof, On Behalf Of The Tb Sequel Consortium
Format: Article
Language:English
Subjects:
Antiretroviral therapy
Biomarkers
Complications and side effects
Drug resistance
Drug therapy
Health aspects
HIV
HIV infection
Human immunodeficiency virus
Infections
Inflammation
Interstitial collagenase
Leukocytes (neutrophilic)
Matrix metalloproteinase
Mediators
Microscopy
multiplex
Neutrophil collagenase
Neutrophils
Patient outcomes
patients living with HIV
Plasma
Plasma levels
Software
Spirometry
Sputum
TB treatment
Tuberculosis
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Summary:The mycobacteriological analysis of sputum samples is the gold standard for tuberculosis diagnosis and treatment monitoring. However, sputum production can be challenging after the initiation of TB treatment. As a possible alternative, we therefore investigated the dynamics of neutrophil-derived soluble inflammatory mediators during TB treatment in relation to HIV ART status and the severity of lung impairment. Plasma samples of TB patients with (N = 47) and without HIV (N = 21) were analyzed at baseline, month 2, month 6 (end of TB treatment) and month 12. Plasma levels of MMP-1, MMP-8, MPO and S100A8 markedly decreased over the course of TB treatment and remained at similar levels thereafter. Post-TB treatment initiation, significantly elevated plasma levels of MMP-8 were detected in TB patients living with HIV, especially if they were not receiving ART treatment at baseline. Our data confirm that the plasma levels of neutrophil-based biomarkers can be used as candidate surrogate markers for TB treatment outcome and HIV-infection influenced MMP-8 and S100A8 levels. Future studies to validate our results and to understand the dynamics of neutrophils-based biomarkers post-TB treatment are needed.
ISSN:2076-0817
2076-0817
DOI:10.3390/pathogens12060794