Prevalence of Periodontal Pathogens in Slovak Patients with Periodontitis and Their Possible Aspect of Transmission from Companion Animals to Humans

Oral health and diseases are greatly influenced by oral bacteria. During dysbiosis, bacterial composition changes, which can lead to periodontitis. Periodontitis in humans is associated with periodontal pathogens such as Treponema denticola, Porphyromonas gingivalis, Tannerella forsythia and Aggrega...

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Published in:Biology (Basel, Switzerland) Switzerland), 2022-10, Vol.11 (10), p.1529
Main Authors: Sondorová, Miriam, Kučera, Ján, Kačírová, Jana, Krchová Nagyová, Zuzana, Šurín Hudáková, Natália, Lipták, Tomáš, Maďar, Marián
Format: Article
Language:English
Subjects:
Aggregatibacter actinomycetemcomitans
Amoxicillin
Animals
Antibiotics
Bacteria
Clavulanic acid
Clindamycin
companion animals
Dental plaque
Disease
Dysbacteriosis
Ethics
Glycerol
humans
Inflammation
Metronidazole
Moxifloxacin
Pathogenesis
Pathogens
Periodontal diseases
periodontal pathogens
Periodontitis
Pharmacy
Phenols
Porphyromonas
Porphyromonas gingivalis
Porphyromonas gulae
Tannerella forsythia
Teeth
transmission
Treponema denticola
Veterinary medicine
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Summary:Oral health and diseases are greatly influenced by oral bacteria. During dysbiosis, bacterial composition changes, which can lead to periodontitis. Periodontitis in humans is associated with periodontal pathogens such as Treponema denticola, Porphyromonas gingivalis, Tannerella forsythia and Aggregatibacter actinomycetemcomitans. Animal-to-human transmission of some of these pathogens has also been reported. The aim of this study was to evaluate the prevalence of periodontal pathogens in Slovak patients and to assess the possible risk of transmission of these pathogens from animals to their owners. The presence of periodontal pathogens in dental plaque was monitored by PCR. Amplified products were analysed using Sanger sequencing. T. forsythia isolates were assessed for the susceptibility to different antibiotics using the disk diffusion method. In humans, T. denticola, P. gingivalis, T. forsythia and A. actinomycetemcomitans were present in 69.23%, 69.23%, 100% and 84.62%, respectively. Most isolates of T. forsythia were susceptible to amoxicillin-clavulanic acid, clindamycin and moxifloxacin, but they were resistant to metronidazole. The transmission of T. forsythia from animals to their owners was not proven based on sequence analysing. On the other hand, transmission of Porphyromonas gulae was confirmed, but the risk of its involvement in the pathogenesis of periodontitis in humans must be further investigated.
ISSN:2079-7737
2079-7737
DOI:10.3390/biology11101529