Enhanced peer-group strategies to support the prevention of mother-to-child HIV transmission leads to increased retention in care in Uganda: A randomized controlled trial

• Published in: PloS one 2024-04, Vol.19 (4), p.e0297652-e0297652
• Main Authors: Amone, Alexander, Gabagaya, Grace, Wavamunno, Priscilla, Rukundo, Gordon, Namale-Matovu, Joyce, Malamba, Samuel S, Lubega, Irene, Homsy, Jaco, King, Rachel, Nakabiito, Clemensia, Namukwaya, Zikulah, Fowler, Mary Glenn, Musoke, Philippa
• Format: Article
• Language: English
• Subjects: Analysis; Anti-HIV Agents - therapeutic use; Antiviral agents; Disease transmission; Dosage and administration; Female; HIV; HIV infection in children; HIV Infections - drug therapy; HIV Infections - prevention & control; Human health and pathology; Humans; Immunology; Infant; Infectious Disease Transmission, Vertical - prevention & control; Infectious diseases; Life Sciences; Maternal-fetal exchange; Mothers; Peer Group; Pregnancy; Pregnancy Complications, Infectious - drug therapy; Pregnancy Complications, Infectious - prevention & control; Prevention; Retention in Care; Risk factors; Uganda
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0297652

Despite the scale-up of Option B+, long-term retention of women in HIV care during pregnancy and the postpartum period remains an important challenge. We compared adherence to clinic appointments and antiretroviral therapy (ART) at 6 weeks, 6, and and 24 months postpartum among pregnant women living with HIV and initiating Option B+. Women were randomized to a peer group support, community-based drug distribution and income-generating intervention called "Friends for Life Circles" (FLCs) versus the standard of care (SOC). Our secondary outcome was infant HIV status and HIV-free survival at 6 weeks and 18 months postpartum. Between 16 May 2016 and 12 September 2017, 540 ART-naïve pregnant women living with HIV at urban and rural health facilities in Uganda were enrolled in the study at any gestational age. Participants were randomized 1:1 to the unblinded FLC intervention or SOC at enrolment and assessed for adherence to the prevention of mother-to-child HIV transmission (PMTCT) clinic appointments at 6 weeks, 12, and 24 months postpartum, self-reported adherence to ART at 6 weeks, 6 and 24 months postpartum and supported by plasma HIV-1 RNA viral load (VL) measured at the same time points, retention in care through the end of study, and HIV status and HIV-free survival of infants at 18 months postpartum. The FLC groups were formed during pregnancy within 4 months of enrollment and held monthly meetings in their communites, and were followed up until the last group participant reached 24 months post delivery. We used Log-rank and Chi-Square p-values to test the equality of Kaplan-Meier survival probabilities and hazard rates (HR) for failure to retain in care for any reason by study arm. There was no significant difference in adherence to PMTCT clinic visits or to ART or in median viral loads between FLC and SOC arms at any follow-up time points. Retention in care through the end of study was high in both arms but significantly higher among participants randomized to FLC (86.7%) compared to SOC (79.3%), p = 0.022. The adjusted HR of visit dropout was 2.4 times greater among participants randomized to SOC compared to FLC (aHR = 2.363, 95% CI: 1.199-4.656, p = 0.013). Median VL remained < 400 copies/ml in both arms at 6 weeks, 6, and 24 months postpartum. Eight of the 431 infants tested at 18 months were HIV positive (1.9%), however, this was not statistically different among mothers enrolled in the FLC arm compared to those in the SOC arm. At 18 months, HIV-