Multifocal skull-compensated transcranial focused ultrasound system for neuromodulation applications based on acoustic holography

Transcranial focused ultrasound stimulation is a promising therapeutic modality for human brain disorders because of its noninvasiveness, long penetration depth, and versatile spatial control capability through beamforming and beam steering. However, the skull presents a major hurdle for successful...

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Bibliographic Details
Published in:Microsystems & nanoengineering 2023-04, Vol.9 (1), p.45-45, Article 45
Main Authors: Kook, Geon, Jo, Yehhyun, Oh, Chaerin, Liang, Xiaojia, Kim, Jaewon, Lee, Sang-Mok, Kim, Subeen, Choi, Jung-Woo, Lee, Hyunjoo Jenny
Format: Article
Language:English
Subjects:
639/166/987
639/925/927/359
Aberration
Acoustics
Beam steering
Beamforming
Brain
Conjugation
Engineering
Exploratory behavior
Holography
Microelectromechanical systems
Neuromodulation
Penetration depth
Phase conjugation
Skull
Stimulation
Three dimensional printing
Ultrasonic imaging
Ultrasound
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Summary:Transcranial focused ultrasound stimulation is a promising therapeutic modality for human brain disorders because of its noninvasiveness, long penetration depth, and versatile spatial control capability through beamforming and beam steering. However, the skull presents a major hurdle for successful applications of ultrasound stimulation. Specifically, skull-induced focal aberration limits the capability for accurate and versatile targeting of brain subregions. In addition, there lacks a fully functional preclinical neuromodulation system suitable to conduct behavioral studies. Here, we report a miniature ultrasound system for neuromodulation applications that is capable of highly accurate multiregion targeting based on acoustic holography. Our work includes the design and implementation of an acoustic lens for targeting brain regions with compensation for skull aberration through time-reversal recording and a phase conjugation mirror. Moreover, we utilize MEMS and 3D-printing technology to implement a 0.75-g lightweight neuromodulation system and present in vivo characterization of the packaged system in freely moving mice. This preclinical system is capable of accurately targeting the desired individual or multitude of brain regions, which will enable versatile and explorative behavior studies using ultrasound neuromodulation to facilitate widespread clinical adoption.
ISSN:2055-7434
2096-1030
2055-7434
DOI:10.1038/s41378-023-00513-3