Inflammation in Prostate Cancer: Exploring the Promising Role of Phenolic Compounds as an Innovative Therapeutic Approach

Prostate cancer (PCa) remains a significant global health concern, being a major cause of cancer morbidity and mortality worldwide. Furthermore, profound understanding of the disease is needed. Prostate inflammation caused by external or genetic factors is a central player in prostate carcinogenesis...

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Bibliographic Details
Published in:Biomedicines 2023-11, Vol.11 (12), p.3140
Main Authors: Fernandes, Raquel, Costa, Cátia, Fernandes, Rúben, Barros, Ana Novo
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
B cells
Bioactive compounds
Biopsy
Carcinogenesis
Development and progression
Disease prevention
Family medical history
Genetic factors
Health aspects
immune response
Inflammation
Leukocytes
Medical innovations
Medical research
Medicine, Experimental
Metastases
Morbidity
Mortality
Nanoparticles
Phenolic compounds
polyphenol compounds
polyphenol-based nanoparticles
Polyphenols
Prostate cancer
Public health
Risk factors
Roles
Tumors
World health
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Summary:Prostate cancer (PCa) remains a significant global health concern, being a major cause of cancer morbidity and mortality worldwide. Furthermore, profound understanding of the disease is needed. Prostate inflammation caused by external or genetic factors is a central player in prostate carcinogenesis. However, the mechanisms underlying inflammation-driven PCa remain poorly understood. This review dissects the diagnosis methods for PCa and the pathophysiological mechanisms underlying the disease, clarifying the dynamic interplay between inflammation and leukocytes in promoting tumour development and spread. It provides updates on recent advances in elucidating and treating prostate carcinogenesis, and opens new insights for the use of bioactive compounds in PCa. Polyphenols, with their noteworthy antioxidant and anti-inflammatory properties, along with their synergistic potential when combined with conventional treatments, offer promising prospects for innovative therapeutic strategies. Evidence from the use of polyphenols and polyphenol-based nanoparticles in PCa revealed their positive effects in controlling tumour growth, proliferation, and metastasis. By consolidating the diverse features of PCa research, this review aims to contribute to increased understanding of the disease and stimulate further research into the role of polyphenols and polyphenol-based nanoparticles in its management.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11123140