P-selectin (CD62P) and soluble TREM-like transcript-1 (sTLT-1) are associated with coronary artery disease: a case control study

Platelet activation plays a crucial role in the pathogenesis of coronary artery disease (CAD). Platelet P-selectin (CD62P) is a classic platelet activation indicator on the platelet surface, and soluble TREM-like transcript-1 (sTLT-1) is a new indicator. However, the relationship between these two m...

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Bibliographic Details
Published in:BMC cardiovascular disorders 2020-08, Vol.20 (1), p.387-387, Article 387
Main Authors: Shen, Li, Yang, Tianlun, Xia, Ke, Yan, Zhiqiang, Tan, Juanjuan, Li, Lei, Qin, Yingchun, Shi, Wei
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - blood
Acute Coronary Syndrome - diagnostic imaging
Acute coronary syndromes
Acute myocardial infarction
Aged
Angina
Angina pectoris
Atherosclerosis
Biomarkers - blood
Blood platelets
Blood Platelets - metabolism
Blood pressure
Body mass index
Cardiovascular disease
Case-Control Studies
CD62P, platelet P-selectin ligand
Coronary artery
Coronary artery disease
Coronary Artery Disease - blood
Coronary Artery Disease - diagnostic imaging
Coronary vessels
Female
Heart attacks
Heart diseases
Humans
Ischemia
Laboratories
Male
Middle Aged
Myocardial infarction
P-selectin
P-Selectin - blood
Plasma
Platelet Activation
Platelets
Receptors, Immunologic - blood
Risk factors
Soluble TREM-like transcript-1
Statistical analysis
Thrombosis
Transcription
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Summary:Platelet activation plays a crucial role in the pathogenesis of coronary artery disease (CAD). Platelet P-selectin (CD62P) is a classic platelet activation indicator on the platelet surface, and soluble TREM-like transcript-1 (sTLT-1) is a new indicator. However, the relationship between these two markers and CAD, especially in acute coronary syndrome (ACS), has not been elucidated. This study aimed to investigate CD62P expression on the platelet surface and sTLT-1 expression in serum, as well as to assess their relationship with CAD. We measured the levels of CD62P and sTLT-1 in 83 patients with CAD compared to 49 controls. The association of these indicators with age, blood pressure, lipid profile, body mass index, and liver injury marker level were also examined. CD62P concentration was higher in CAD patients than in the control group (P 
ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-020-01663-2