Chemokine Receptor 2 (CXCR2) Gene Polymorphisms and Their Association with the Risk of Developing Peri-Implantitis in Chinese Han Population

This study aimed to investigate the role of chemokine receptor 2 ( ) gene polymorphisms in peri-implantitis susceptibility in a Chinese Han population. A total of 260 individuals were included in this study, including 127 peri-implantitis patients and 133 healthy implants. gene rs2230054 and rs11265...

Full description

Saved in:
Bibliographic Details
Published in:Journal of inflammation research 2021-01, Vol.14, p.1625-1631
Main Authors: Qi, Yuesun, Li, Cheng, Du, Yimin, Lin, Jichao, Li, Nan, Yu, Youcheng
Format: Article
Language:English
Subjects:
Alleles
chemokine receptor 2 (cxcr2)
Chemokine receptors
Chemokines
CXCR2 protein
Cytokines
Dentistry
Disease susceptibility
Gene polymorphism
Genes
Genetic aspects
Genetic polymorphisms
Genotype & phenotype
han population
Original Research
Pathogenesis
peri-implantitis
Polymorphism
Population
Population studies
Risk factors
Transplants & implants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to investigate the role of chemokine receptor 2 ( ) gene polymorphisms in peri-implantitis susceptibility in a Chinese Han population. A total of 260 individuals were included in this study, including 127 peri-implantitis patients and 133 healthy implants. gene rs2230054 and rs1126580 polymorphisms in different groups were analyzed by the Chi-square test. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were employed to evaluate the association between polymorphism and peri-implantitis susceptibility. The CT genotype of rs2230054 and the AG genotype and G allele of rs1126580 significantly increased in peri-implantitis patients compared with healthy implants ( < 0.05). The CT genotype of rs2230054 (OR = 1.825, 95% CI = 1.028-3.239) and the AG genotype of rs1126580 (OR = 2.223, 95% CI 1.272-3.885) carriers had a high risk to infect with peri-implantitis. Additionally, these gene polymorphisms have been revealed to be associated with the periodontal status of peri-implantitis patients. The CXCR2 gene rs2230054 and rs1126580 polymorphisms were associated with the peri-implantitis susceptibility in the Chinese Han population. The CT genotype of rs2230054 and the AG genotype and G allele of rs1126580 serve as risk factors for the occurrence of peri-implantitis.
ISSN:1178-7031
1178-7031
DOI:10.2147/JIR.S304261