The role of noncoding RNAs in the osteogenic differentiation of human periodontal ligament-derived cells

Human periodontal ligament-derived cells are important seed cells for periodontal regeneration, and their osteogenic potential closely affects alveolar bone repair and periodontal regeneration. Human periodontal ligament stem cells are pluripotent stem cells of mesenchymal origin, which can differen...

Full description

Saved in:
Bibliographic Details
Published in:Non-coding RNA research 2023-03, Vol.8 (1), p.89-95
Main Authors: Sufianov, Albert, Beilerli, Aferin, Begliarzade, Sema, Ilyasova, Tatiana, Kudriashov, Valentin, Liang, Yanchao, Beylerli, Ozal
Format: Article
Language:English
Subjects:
Circular RNA
Long non-coding RNA
microRNA
Osteogenic differentiation
Periodontal ligament cell
Periodontal ligament stem cell
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Human periodontal ligament-derived cells are important seed cells for periodontal regeneration, and their osteogenic potential closely affects alveolar bone repair and periodontal regeneration. Human periodontal ligament stem cells are pluripotent stem cells of mesenchymal origin, which can differentiate in osteoblasts and cementoblasts. However, the molecular mechanism of this differentiation activity is poorly studied. Noncoding RNAs (ncRNAs) belong to RNAs, which do not encode proteins and represent a large segment of the human transcriptome, mainly including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). It was shown that ncRNAs is involved in the proliferation and differentiation of cells, epigenetic modifications, apoptosis, as well as in complex control and pathogenesis of various diseases. NcRNAs are actively involved in the regulation of osteogenic genes in human periodontal ligament-derived cells. This article reviews the research progress of ncRNAs in the regulatory targets, pathways and functions of ncRNAs in the osteogenic differentiation of human periodontal ligament-derived cells.
ISSN:2468-0540
2468-0540
DOI:10.1016/j.ncrna.2022.11.003