Effect of tetanus-diphtheria vaccine on immune response to Hepatitis b vaccine in low-responder individuals

• Published in: International journal of preventive medicine 2016-01, Vol.7 (1), p.94-94
• Main Authors: Haghighat, Abbas, Moafi, Mohammad, Sharifian, Jalil, Salehi, Hassan, Taleban, Roya, Kalbasi, Nader, Salehi, Marzieh, Salehi, Mohammad, Salehi, Maryam
• Format: Article
• Language: English
• Subjects: Antigens; Chemokines; Clinical trials; Diphtheria antitoxins; Dosage and administration; Hemodialysis; Hepatitis; Hepatitis B; Hepatitis B vaccine; Immune response; Infections; low responders; Original; Prevention; Response rates; Studies; Tetanus; tetanus-diphtheria vaccine; Vaccines
• ISSN: 2008-7802; 2008-8213
• DOI: 10.4103/2008-7802.186586

Background: Conventional hepatitis B virus (HBV) vaccination fails to achieve efficient protection in about 5-10% of the world population. Hence, different strategies have been adopted to ameliorate HBV antibody titers. This study aimed to evaluate the concurrent application of tetanus-diphtheria (Td) and HBV vaccination on hepatitis B surface (HBs) antibody titer in low-responder healthy individuals. Methods: This was a randomized clinical trial, which was implemented among 140 of medical staff working as health-care workers assumed as low-responders. The subjects were randomly allocated to either control or interventional groups. The control and interventional groups received HBV recombinant vaccine while the latter group was also vaccinated through Td. Enzyme-linked immunosorbent assay was applied to measure HBs antibody (HBsAb) titers just before and 6 months after the last vaccination. All data were entered into SPSS software. Independent t-test, paired t-test, and Chi-square or Fisher′s exact test were applied for data comparison. Results: Antibody titers of the subjects in the intervention and control groups soared from 49.08 ± 20.08 IU/L to 917.78 ± 204.80 IU/L and from 46.95 ± 18.55 to 586.81 ± 351.77 IU/L, respectively (both P < 0.001); nevertheless, by comparison with control group, variation of antibody titer in the interventional group was significantly higher (P < 0.001). Conclusions: Concurrent application of Td and HBV vaccine could effectively enhance protective levels of HBsAb titers in low-responder individuals.