The proteinuria selectivity index value predicts the remission of IgA nephropathy: a retrospective cohort study

IgA nephropathy (IgAN) is the most common type of primary glomerulonephritis worldwide and leads to end-stage kidney disease. The proteinuria selectivity index (PSI) has been used to assess the prognosis in nephrotic syndrome, but its predictive value in patients with IgAN remains unclear. This sing...

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Bibliographic Details
Published in:Renal failure 2024-12, Vol.46 (2), p.2423839
Main Authors: Mitsuno, Ryunosuke, Nakayama, Takashin, Ito, Wataru, Maruki, Tomomi, Nakamichi, Ran, Adachi, Keika, Yoshimoto, Norifumi, Hishikawa, Akihito, Hagiwara, Aika, Yamaguchi, Shintaro, Monkawa, Toshiaki, Yoshino, Jun, Hashiguchi, Akinori, Azegami, Tatsuhiko, Hayashi, Kaori
Format: Article
Language:English
Subjects:
Adult
Biomarker
Biopsy
Creatinine - blood
Creatinine - urine
Female
Glomerulonephritis and Immunologic Disorders
Glomerulonephritis, IGA - complications
Glomerulonephritis, IGA - diagnosis
Humans
IgA nephropathy
Kidney - pathology
Kidney - physiopathology
Male
Middle Aged
Prognosis
Proportional Hazards Models
proteinuria
Proteinuria - etiology
proteinuria selectivity index
Remission Induction
Retrospective Studies
ROC Curve
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Summary:IgA nephropathy (IgAN) is the most common type of primary glomerulonephritis worldwide and leads to end-stage kidney disease. The proteinuria selectivity index (PSI) has been used to assess the prognosis in nephrotic syndrome, but its predictive value in patients with IgAN remains unclear. This single-center retrospective cohort study included patients who diagnosed with IgAN between March 2012 and March 2020. The PSI was calculated at the time of kidney biopsy. Patients were followed up from the time of kidney biopsy to kidney replacement therapy, death, transfer to another facility, or study completion. Ninety-four patients with a median age of 51 years were enrolled and divided according to the cutoff value of PSI determined by the receiver operating characteristic curve analysis into low-PSI (PSI
ISSN:0886-022X
1525-6049
1525-6049
DOI:10.1080/0886022X.2024.2423839