Ligand Binding and Signaling of HARE/Stabilin-2

The Stabilin receptors are a two-member family in the type H class of scavenger receptors. These dynamic receptors bind and internalize multiple ligands from the cell surface for the purpose of clearing extracellular material including some synthetic drugs and for sensing the external environment of...

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Bibliographic Details
Published in:Biomolecules (Basel, Switzerland) Switzerland), 2019-07, Vol.9 (7), p.273
Main Authors: Harris, Edward N, Cabral, Fatima
Format: Article
Language:English
Subjects:
Animals
Cell Adhesion Molecules, Neuronal - metabolism
Endocytosis - physiology
HARE
Humans
hyaluronan
Hyaluronic Acid - metabolism
receptor-mediated endocytosis
Receptors, Scavenger - metabolism
Review
scavenger receptor
Signal Transduction - physiology
stabilin
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Summary:The Stabilin receptors are a two-member family in the type H class of scavenger receptors. These dynamic receptors bind and internalize multiple ligands from the cell surface for the purpose of clearing extracellular material including some synthetic drugs and for sensing the external environment of the cell. Stabilin-1 was the first receptor to be cloned, though the biological activity of Hyaluronic Acid Receptor for Endocytosis (HARE)/Stabilin-2 was observed about 10 years prior to the cloning of Stabilin-1. Stabilin-1 has a more diverse expression profile among the tissues than HARE/Stabilin-2. This review will focus on HARE/Stabilin-2 and its interactions with hyaluronan, heparin, and phosphorothioate antisense oligonucleotides and what is known about how this receptor participates in signaling upon ligand binding.
ISSN:2218-273X
2218-273X
DOI:10.3390/biom9070273