Advances in novel activation methods to perform green organic synthesis using recyclable heteropolyacid catalysis

• Published in: Green processing and synthesis 2022-08, Vol.11 (1), p.766-809
• Main Authors: Ruiz, Diego M., Pasquale, Gustavo A., Martínez, José J., Romanelli, Gustavo P.
• Format: Article
• Language: English
• Subjects: Acidity; Alternative energy sources; Atom economy; Biocompatibility; Biological activity; Catalysis; Catalysts; Catalytic activity; Chemical synthesis; Economics; Energy consumption; Energy efficiency; Environmental impact; Green chemistry; heteropolyacids; Microwaves; novel chemical activation methods; Organic chemistry; organic transformations; Oxidation; Photochemistry; Substrates; Ultrasonic imaging
• ISSN: 2191-9550; 2191-9542; 2191-9550
• DOI: 10.1515/gps-2022-0068

Highly functionalized, high value added bioactive molecules are generally obtained by synthetic procedures that are highly selective, economical, with high atom economy, and environmentally friendly. Following these guidelines, the use of recoverable solid catalysts, nonpolluting substrates, or toxic organic solvent contributes greatly to these demands. In the last three decades, heteropolyacids (HPAs) and its derivatives have received great attention as recyclable solid catalysts, due to their strong Brönsted acidity, excellent oxidizing capacity under mild conditions, and various reuse cycles without appreciable loss of their catalytic activity. However, new activation methods should be investigated to improve the sustainability of a process using HPAs. In this review, we report the latest advances associated with the synthesis of potentially bioactive molecules using more energy efficient alternatives such as microwaves, ultrasound, mechanochemistry, and photochemistry to minimize the energy consumption associated with organic synthesis. The transformations studied include construction reaction, heterocycle synthesis, selective oxidation, and biomass recovery.