Transcription Factors in the Pathogenesis of Lupus Nephritis and Their Targeted Therapy

Systemic lupus erythematosus (SLE) is a prototype inflammatory autoimmune disease, characterized by breakdown of immunotolerance to self-antigens. Renal involvement, known as lupus nephritis (LN), is one of the leading causes of morbidity and a significant contributor to mortality in SLE. Despite cu...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-01, Vol.25 (2), p.1084
Main Authors: Shao, Kasey M, Shao, Wen-Hai
Format: Article
Language:English
Subjects:
Autoantigens
B cells
Belimumab
Clinical trials
Cytokines
Development and progression
DNA binding proteins
Gene expression
Genes
Health aspects
Humans
Immune system
Inflammation
Kidney diseases
Kinases
Lupus
Lupus Erythematosus, Systemic
lupus nephritis
Lupus Nephritis - etiology
Lupus Nephritis - genetics
Mortality
Nephritis
Pathogenesis
Phosphorylation
Proteins
Systemic lupus erythematosus
targeted therapy
transcription factor
Transcription factors
Transcription Factors - genetics
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Summary:Systemic lupus erythematosus (SLE) is a prototype inflammatory autoimmune disease, characterized by breakdown of immunotolerance to self-antigens. Renal involvement, known as lupus nephritis (LN), is one of the leading causes of morbidity and a significant contributor to mortality in SLE. Despite current pathophysiological advances, further studies are needed to fully understand complex mechanisms underlying the development and progression of LN. Transcription factors (TFs) are proteins that regulate the expression of genes and play a crucial role in the development and progression of LN. The mechanisms of TF promoting or inhibiting gene expression are complex, and studies have just begun to reveal the pathological roles of TFs in LN. Understanding TFs in the pathogenesis of LN can provide valuable insights into this disease's mechanisms and potentially lead to the development of targeted therapies for its management. This review will focus on recent findings on TFs in the pathogenesis of LN and newly developed TF-targeted therapy in renal inflammation.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25021084