High expression of RUVBL1 and HNRNPU is associated with poor overall survival in stage I and II non-small cell lung cancer patients

The present study aimed to investigate expression levels and prognostic significance of RUVBL1 and HNRNPU in stage I and II non–small-cell lung cancer (NSCLC) patients. Therefore, we evaluated immunohistochemical staining of RUVBL1 and HNRNPU, as well as RNA-seq data from public sources, and the res...

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Bibliographic Details
Published in:Discover. Oncology 2022-10, Vol.13 (1), p.106-106, Article 106
Main Authors: Durślewicz, Justyna, Jóźwicki, Jakub, Klimaszewska-Wiśniewska, Anna, Zielińska, Aleksandra, Antosik, Paulina, Grzanka, Dariusz, Braun, Marcin
Format: Article
Language:English
Subjects:
Cancer Research
HNRNPU
Internal Medicine
Medicine
Medicine & Public Health
Molecular Medicine
Non-small cell lung cancer
NSCLC
Nuclear matrix protein
Oncology
Prognostic biomarkers
Radiotherapy
RUVBL1
Surgical Oncology
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Summary:The present study aimed to investigate expression levels and prognostic significance of RUVBL1 and HNRNPU in stage I and II non–small-cell lung cancer (NSCLC) patients. Therefore, we evaluated immunohistochemical staining of RUVBL1 and HNRNPU, as well as RNA-seq data from public sources, and the results were evaluated concerning overall survival (OS) and clinicopathological features. We found that RUVBL1 and HNRNPU proteins and mRNA levels were higher in tumor tissues as compared to adjacent/normal tissues. RUVBL1 (p = 0.013) and HNRNPU (p = 0.021) high protein levels were independent prognostic factors for poor OS. Also, the multivariate analysis in the TCGA dataset revealed that high RUVBL1 (p = 0.064) and HNRNPU (p = 0.181) mRNA levels were not significantly associated with prognosis. However, the co-expression status of these markers (R + H +) was independently associated with poor OS both in the TCGA dataset (p = 0.027) and in our cohort (p = 0.001). In conclusion, combined and individual expression of RUVBL1 and HNRNPU proteins, as well as R + H + mRNA status, may serve as potential prognostic biomarkers for NSCLC. This study adds to the previous observations that RUVBL1 and HNRNPU might be novel and promising therapeutic targets and markers for prognostic evaluation.
ISSN:2730-6011
2730-6011
DOI:10.1007/s12672-022-00568-0