Efficient self-assembly of heterometallic triangular necklace with strong antibacterial activity

• Published in: Nature communications 2020-06, Vol.11 (1), p.3178-11, Article 3178
• Main Authors: Wu, Gui-Yuan, Shi, Xueliang, Phan, Hoa, Qu, Hang, Hu, Yi-Xiong, Yin, Guang-Qiang, Zhao, Xiao-Li, Li, Xiaopeng, Xu, Lin, Yu, Qilin, Yang, Hai-Bo
• Format: Article
• Language: English
• Subjects: 14/28; 14/3; 147/135; 147/143; 639/638/541; 639/638/911; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Bacteria; Bacteria - drug effects; Binding; Cell culture; Cell walls; Coordination compounds; Copper; Copper - chemistry; Crystallography, X-Ray; Culture media; DNA Cleavage - drug effects; Drug resistance; Drug Resistance, Bacterial - drug effects; Enantiomers; Heavy metals; Humanities and Social Sciences; Ligands; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Models, Molecular; Molecular Structure; multidisciplinary; Nuclease; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Platinum; Platinum - chemistry; Science; Science (multidisciplinary); Self-assembly; Single crystals; Stereoisomerism; Synergistic effect; X ray analysis
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-020-16940-z

Sophisticated mechanically interlocked molecules (MIMs) with interesting structures, properties and applications have attracted great interest in the field of supramolecular chemistry. We herein report a highly efficient self-assembly of heterometallic triangular necklace 1 containing Cu and Pt metals with strong antibacterial activity. Single-crystal X-ray analysis shows that the finely arranged triangular necklace 1 has two racemic enantiomers in its solid state with intriguing packing motif. The superior antibacterial activity of necklace 1 against both standard and clinically drug-resistant pathogens implies that the presence of Cu(I) center and platinum(II) significantly enhance the bacterium-binding/damaging activity, which is mainly attributed to the highly positively charged nature, the possible synergistic effect of heterometals in the necklace, and the improved stability in culture media. This work clearly discloses the structure-property relationships that the existence of two different metal centers not only facilitates successful construction of heterometallic triangular necklace but also endows it with superior nuclease properties and antibacterial activities. Precise assembly of heterometallic complexes is a challenge. Here, the authors design a heterometallic triangular necklace through a highly efficient threading-and-ring-closing approach driven by metal-ligand coordination, which shows strong bacterium-binding and cell wall/plasma membrane-disrupting capacity for killing bacterial cells.