Mild thermotherapy and hyperbaric oxygen enhance sensitivity of TMZ/PSi nanoparticles via decreasing the stemness in glioma

Glioma is a common brain tumor with a high mortality rate. A small population of cells expressing stem-like cell markers in glioma contributes to drug resistance and tumor recurrence. Porous silicon nanoparticles (PSi NPs) as photothermal therapy (PTT) agents loaded with TMZ (TMZ/PSi NPs), was combi...

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Bibliographic Details
Published in:Journal of nanobiotechnology 2019-04, Vol.17 (1), p.47-47, Article 47
Main Authors: Zeng, Xiaofan, Wang, Qi, Tan, Xuan, Jia, Le, Li, Yuwei, Hu, Mingdi, Zhang, Zhijie, Bai, Xicheng, Zhu, Yanhong, Yang, Xiangliang
Format: Article
Language:English
Subjects:
Anticancer properties
Antitumor activity
Brain
Brain cancer
Brain tumors
Cancer therapies
Chemotherapy
Drug dosages
Drug resistance
Drug therapy
Evolution & development
Glioma
Glioma cells
Gliomas
Growth factors
Health aspects
Hyperbaric oxygen
Hyperthermia
Hypoxia
In vivo methods and tests
Markers
Medical prognosis
Nanoparticles
Photothermal therapy
Physiological aspects
Porous silicon
Porous silicon nanoparticles
Properties
Sensitivity enhancement
Silicon
Silicon wafers
Stem cells
Stemness
Therapy
Thermotherapy
Tumors
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Summary:Glioma is a common brain tumor with a high mortality rate. A small population of cells expressing stem-like cell markers in glioma contributes to drug resistance and tumor recurrence. Porous silicon nanoparticles (PSi NPs) as photothermal therapy (PTT) agents loaded with TMZ (TMZ/PSi NPs), was combined with hyperbaric oxygen (HBO) therapy in vitro and in vivo. To further investigate underlying mechanism, we detected the expression of stem-like cell markers and hypoxia related molecules in vitro and in vivo after treatment of TMZ/PSi NPs in combination with PTT and HBO. NCH-421K and C6 cells were more sensitive to the combination treatment. Moreover, the expression of stem-like cell markers and hypoxia related molecules were decreased after combination treatment. The in vivo results were in line with in vitro. The combination treatment presents significant antitumor effects in mice bearing C6 tumor compared with the treatment of TMZ, PTT or TMZ/PSi NPs only. These results suggested the TMZ/PSi NPs combined with HBO and PTT could be a potential therapeutic strategy for glioma.
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-019-0483-1