Genetic and Epigenetic Regulation of CCR5 Transcription

The chemokine receptor CCR5 regulates trafficking of immune cells of the lymphoid and the myeloid lineage (such as monocytes, macrophages and immature dendritic cells) and microglia. Because of this, there is an increasing recognition of the important role of CCR5 in the pathology of (neuro-) inflam...

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Published in:Biology (Basel, Switzerland) Switzerland), 2012-12, Vol.1 (3), p.869-879
Main Authors: Wierda, Rutger J, van den Elsen, Peter J
Format: Article
Language:English
Subjects:
atherosclerosis
binding proteins
CCR5
CCR5 receptor
chromatin
dendritic cells
DNA methylation
epigenetics
genes
macrophages
monocytes
multivalent chromatin
neuroglia
promoter regions
Review
sclerosis
transcription (genetics)
transcription factors
transcription regulation
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description The chemokine receptor CCR5 regulates trafficking of immune cells of the lymphoid and the myeloid lineage (such as monocytes, macrophages and immature dendritic cells) and microglia. Because of this, there is an increasing recognition of the important role of CCR5 in the pathology of (neuro-) inflammatory diseases such as atherosclerosis and multiple sclerosis. Expression of CCR5 is under the control of a complexly organized promoter region upstream of the gene. The transcription factor cAMP-responsive element binding protein 1 (CREB-1) transactivates the CCR5 P1 promoter. The cell-specific expression of CCR5 however is realized by using various epigenetic marks providing a multivalent chromatin state particularly in monocytes. Here we discuss the transcriptional regulation of CCR5 with a focus on the epigenetic peculiarities of CCR5 transcription.
doi_str_mv 10.3390/biology1030869
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subjects atherosclerosis
binding proteins
CCR5
CCR5 receptor
chromatin
dendritic cells
DNA methylation
epigenetics
genes
macrophages
monocytes
multivalent chromatin
neuroglia
promoter regions
Review
sclerosis
transcription (genetics)
transcription factors
transcription regulation
title Genetic and Epigenetic Regulation of CCR5 Transcription
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