Mortality risk and causes of death in patients with non-cystic fibrosis bronchiectasis

• Published in: Respiratory research 2019-12, Vol.20 (1), p.271-271, Article 271
• Main Authors: Sin, Sooim, Yun, Seo Young, Kim, Jee Min, Park, Chang Min, Cho, Jaeyoung, Choi, Sun Mi, Lee, Jinwoo, Park, Young Sik, Lee, Sang-Min, Yoo, Chul-Gyu, Kim, Young Whan, Han, Sung Koo, Lee, Chang-Hoon
• Format: Article
• Language: English
• Subjects: Adult; Air flow; Bronchiectasis; Bronchiectasis - diagnostic imaging; Bronchiectasis - mortality; Bronchiectasis - pathology; Cancer; Case-Control Studies; CAT scans; Cause of Death; Chest; Computed tomography; Confidence intervals; Cystic Fibrosis; Death; Diagnostic imaging; Disease control; Female; Fibrosis; Fibrosis - mortality; Fibrosis - pathology; Health risk assessment; Health risks; Hospitals, University; Humans; Infection control; Lung cancer; Lung diseases; Lung Neoplasms - diagnostic imaging; Lung Neoplasms - mortality; Lung Neoplasms - pathology; Male; Medical research; Middle Aged; Mortality; Mortality risk; Patient outcomes; Population; Proportional Hazards Models; Radiography, Thoracic - methods; Reference Values; Regression analysis; Republic of Korea; Respiratory Function Tests; Respiratory tract diseases; Retrospective Studies; Risk Assessment; Risk management; Severity of Illness Index; Smoking; Studies; Subgroups; Survival Analysis; Tomography; Tomography, X-Ray Computed - methods; Tuberculosis; Young Adult
• ISSN: 1465-993X; 1465-9921; 1465-993X; 1465-9921
• DOI: 10.1186/s12931-019-1243-3

All-cause mortality risk and causes of death in bronchiectasis patients have not been fully investigated. The aim of this study was to compare the mortality risk and causes of death between individuals with bronchiectasis and those without bronchiectasis. Patients with or without bronchiectasis determined based on chest computed tomography (CT) at one centre between 2005 and 2016 were enrolled. Among the patients without bronchiectasis, a control group was selected after applying additional exclusion criteria. We compared the mortality risk and causes of death between the bronchiectasis and control groups without lung disease. Subgroup analyses were also performed according to identification of Pseudomonas or non-tuberculous mycobacteria, airflow limitation, and smoking status. Of the total 217,702 patients who underwent chest CT, 18,134 bronchiectasis patients and 90,313 non-bronchiectasis patients were included. The all-cause mortality rate in the bronchiectasis group was 1608.8 per 100,000 person-years (95% confidence interval (CI), 1531.5-1690.0), which was higher than that in the control group (133.5 per 100,000 person-years; 95% CI, 124.1-143.8; P