Phylogenomic Placement of American Southwest-Associated Clinical and Veterinary Isolates Expands Evidence for Distinct Cryptococcus gattii VGVI

Whole-genome sequencing has advanced our understanding of the population structure of the pathogenic species complex Cryptococcus gattii, which has allowed for the phylogenomic specification of previously described major molecular type groupings and novel lineages. Recently, isolates collected in Me...

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Bibliographic Details
Published in:Microorganisms (Basel) 2022-08, Vol.10 (8), p.1681
Main Authors: Monroy-Nieto, Juan, Bowers, Jolene R, Montfort, Parker, Adame, Guillermo, Taverna, Constanza Giselle, Yaglom, Hayley, Sykes, Jane E, Brady, Shane, Mochon, A Brian, Meyer, Wieland, Komatsu, Kenneth, Engelthaler, David M
Format: Article
Language:English
Subjects:
Biogeography
Clinical isolates
Communication
Cryptococcus
Cryptococcus gattii
Epidemiology
Fungi
Gene sequencing
Genomes
Genomic analysis
Hypotheses
Laboratories
molecular type
Pathogens
phylogenomics
Polymorphism
Population
Population structure
VGVI
Whole genome sequencing
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Summary:Whole-genome sequencing has advanced our understanding of the population structure of the pathogenic species complex Cryptococcus gattii, which has allowed for the phylogenomic specification of previously described major molecular type groupings and novel lineages. Recently, isolates collected in Mexico in the 1960s were determined to be genetically distant from other known molecular types and were classified as VGVI. We sequenced four clinical isolates and one veterinary isolate collected in the southwestern United States and Argentina from 2012 to 2021. Phylogenomic analysis groups these genomes with those of the Mexican VGVI isolates, expanding VGVI into a clade and establishing this molecular type as a clinically important population. These findings also potentially expand the known Cryptococcus ecological range with a previously unrecognized endemic area.
ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms10081681